Individual differences in hippocampal volume as a function of BMI and reward sensitivity

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• dc.contributor.author Parcet, Maria-Antònia
• dc.contributor.author Adrián Ventura, Jesús
• dc.contributor.author Costumero, Víctor
• dc.contributor.author Ávila, César
• dc.date.accessioned 2020-05-08T08:38:20Z
• dc.date.available 2020-05-08T08:38:20Z
• dc.date.issued 2020
• dc.description.abstract Sensitivity to reward is a personality trait that predisposes a person to several addictive behaviors, including the presence of different risky behaviors that facilitates uncontrolled eating. However, the multifactorial nature of obesity blurs a direct relationship between the two factors. Here, we studied the brain anatomic correlates of the interaction between reward sensitivity and body mass index (BMI) to investigate whether the coexistence of high BMI and high reward sensitivity structurally alters brain areas specifically involved in the regulation of eating behavior. To achieve this aim, we acquired T1-weighted images and measured reward sensitivity using the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) and BMI in a sample of 206 adults. Results showed that reward sensitivity and BMI were not significantly correlated. However, neuroimaging results confirmed a relationship between BMI and reduced volume in the medial and lateral orbitofrontal cortex, and between reward sensitivity and lower striatum volume. Importantly, the interaction between the two factors was significantly related to the right anterior hippocampus volume, showing that stronger reward sensitivity plus a higher BMI were associated with reduced hippocampal volume. The hippocampus is a brain structure involved in the higher-order regulation of feeding behavior. Thus, a dysfunctional hippocampus may contribute to maintaining a vicious cycle that predisposes people to obesity.en
• dc.description.sponsorship This work was supported by grants from Generalitat Valenciana (AICO/2018/038), Universitat Jaume I (UJI-B2018-22) and Ministerio de Economía y Competitividad (PSI2016-78805-R) to CÁA. This work was also supported by a pre-doctoral graduate program grant (National FPU to JA-V) and a post-doctoral graduate program grant (Juan de la Cierva to VC).
• dc.format.mimetype application/pdf
• dc.identifier.citation Parcet MA, Adrián-Ventura J, Costumero V, Ávila C. Individual differences in hippocampal volume as a function of BMI and reward sensitivity. Front Behav Neurosci. 2020 Apr 9;14:53. DOI: 10.3389/fnbeh.2020.00053
• dc.identifier.doi http://dx.doi.org/10.3389/fnbeh.2020.00053
• dc.identifier.issn 1662-5153
• dc.identifier.uri http://hdl.handle.net/10230/44467
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Behavioral Neuroscience. 2020 Apr 9;14:53
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-78805-R
• dc.rights © 2020 Parcet, Adrián-Ventura, Costumero and Ávila. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Reward sensitivityen
• dc.subject.keyword Body mass indexen
• dc.subject.keyword Hippocampusen
• dc.subject.keyword Voxel-based morphometryen
• dc.subject.keyword Obesityen
• dc.subject.keyword Reinforcement sensitivity theoryen
• dc.title Individual differences in hippocampal volume as a function of BMI and reward sensitivity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion