Thalamocortical interactions shape hierarchical neural variability during stimulus perception

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• dc.contributor.author Tauste Campo, Adrià
• dc.contributor.author Zainos, Antonio
• dc.contributor.author Vázquez, Yuriria
• dc.contributor.author Adell Segarra, Raul
• dc.contributor.author Álvarez, Manuel
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Díaz, Héctor
• dc.contributor.author Parra, Sergio
• dc.contributor.author Romo, Ranulfo
• dc.contributor.author Rossi-Pool, Román
• dc.date.accessioned 2025-06-12T06:10:32Z
• dc.date.available 2025-06-12T06:10:32Z
• dc.date.issued 2024
• dc.description.abstract The brain is organized hierarchically to process sensory signals. But, how do functional connections within and across areas contribute to this hierarchical order? We addressed this problem in the thalamocortical network, while monkeys detected vibrotactile stimulus. During this task, we quantified neural variability and directed functional connectivity in simultaneously recorded neurons sharing the cutaneous receptive field within and across VPL and areas 3b and 1. Before stimulus onset, VPL and area 3b exhibited similar fast dynamics while area 1 showed slower timescales. During the stimulus presence, inter-trial neural variability increased along the network VPL-3b-1 while VPL established two main feedforward pathways with areas 3b and 1 to process the stimulus. This lower variability of VPL and area 3b was found to regulate feedforward thalamocortical pathways. Instead, intra-cortical interactions were only anticipated by higher intrinsic timescales in area 1. Overall, our results provide evidence of hierarchical functional roles along the thalamocortical network.
• dc.description.sponsorship A.T.C. was supported by the Spanish national research project (ref. PID2020-119072RA-I00/AEI/10.13039/501100011033) funded by the Spanish Ministry of Science, Innovation, and Universities (MCIU) and the Bial Foundation grant 106/18. G.D. was supported by the Spanish national research project (ref. PID2019-105772GB-I00/AEI/10.13039/501100011033) funded by the Spanish Ministry of Science, Innovation, and Universities (MCIU). This work was supported by grants PAPIITIN205022 from the Dirección de Asuntos del Personal Académico de la Universidad Nacional Autónoma de México (to R.R.-P.); CONAHCYT-319347 (to R.R.P.) from Consejo Nacional de Ciencia y Tecnología; and IBRO Early Career Award 2022 (to R.R.-P.) from International Brain Research Association.
• dc.format.mimetype application/pdf
• dc.identifier.citation Tauste Campo A, Zainos A, Vázquez Y, Adell Segarra R, Álvarez M, Deco G, et al. Thalamocortical interactions shape hierarchical neural variability during stimulus perception. iScience. 2024 Jul 19;27(7):110065. DOI: 10.1016/j.isci.2024.110065
• dc.identifier.doi http://dx.doi.org/10.1016/j.isci.2024.110065
• dc.identifier.issn 2589-0042
• dc.identifier.uri http://hdl.handle.net/10230/70672
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof iScience. 2024 Jul 19;27(7):110065
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-119072RA-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Cervell -- Estimulació
• dc.subject.other Receptors neuronals
• dc.subject.other Neuroestimulació
• dc.subject.other Xarxes neuronals (Neurobiologia)
• dc.title Thalamocortical interactions shape hierarchical neural variability during stimulus perception
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion