Characterizing the spectrum of right ventricular remodelling in response to chronic training

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  • dc.contributor.author Sitges, Marta
  • dc.contributor.author Merino, Beatriz
  • dc.contributor.author Butakoff, Constantine
  • dc.contributor.author Sanz de la Garza, Maria
  • dc.contributor.author Paré, Carles
  • dc.contributor.author Montserrat, Silvia
  • dc.contributor.author Vidal, Barbara
  • dc.contributor.author Azqueta, Manel
  • dc.contributor.author Sarquella-Brugada, Georgia
  • dc.contributor.author Gutierrez, Josep Antoni
  • dc.contributor.author Canal, Ramon
  • dc.contributor.author Brugada, Josep
  • dc.contributor.author Bijnens, Bart
  • dc.date.accessioned 2019-03-28T08:32:11Z
  • dc.date.available 2019-03-28T08:32:11Z
  • dc.date.issued 2017
  • dc.description.abstract Background: The significance and spectrum of reduced right ventricular (RV) deformation, reported in endurance athletes, is unclear. Purpose: to comprehensively analyze the cardiac performance at rest of athletes, especially focusing on integrating RV size and deformation to unravel the underlying triggers of this ventricular remodelling. Methods: 100 professional male athletes and 50 sedentary healthy males of similar age were prospectively studied. Conventional echocardiographic parameters of all 4 chambers were obtained, as well as 2D echo-derived strain (2DSE) in the left (LV) and in the RV free wall with separate additional analysis of the RV basal and apical segments. Results: Left and right-sided dimensions were larger in athletes than in controls, but with a disproportionate RA enlargement. RV global strain was lower in sportsmen (-26.8 ± 2.8 vs -28.5 ± 3.4%, p<0.001) due to a decrease in the basal segment (-22.8 ± 3.5 vs -25.8 ± 4.0%, p<0.001) resulting in a marked gradient of deformation from the RV inlet towards the apex. By integrating size, deformation and stroke volume, we observed that the LV working conditions were similar in all sportsmen while a wider variability existed in the RV. Conclusions: Cardiac remodelling in athletes is more pronounced in the right heart cavities with specific regional differences within the right ventricle, but with a wide variability among individuals. The large inter-individual differences, as well as its acute and chronic relevance warrant further investigation.
  • dc.description.sponsorship This work was partially funded by grants from the Fundació Clinic (premio Emili Letang, B. Merino), Generalitat de Catalunya (FI-AGAUR 2014-2017 (RH 040991, M. Sanz), and from the Spanish Society of Cardiology (Fundación Española del Corazón Investigación Clínica 2012), the Spanish Government (Plan Nacional I+D+i, Ministerio de Innovación y Ciencia DEP 2011-2013 (DEP 2010-20565); Intensificación Actividad Investigadora, Instituto de Salud Carlos III (M Sitges; PI11/01709); Plan Nacional I+D, Ministerio de Economia y Competitividad DEP2013-44923-P, TIN2014-52923-R and FEDER.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Sitges M, Merino B, Butakoff C, Sanz de la Garza M, Paré C, Montserrat S, Vidal B, Azqueta M, Sarquella G, Gutierrez JA, Canal R, Brugada J, Bijnens B. Characterizing the spectrum of right ventricular remodelling in response to chronic training. Int J Cardiovasc Imaging. 2017 March:33(3):331-9. DOI: 10.1007/s10554-016-1014-x
  • dc.identifier.doi http://dx.doi.org/10.1007/s10554-016-1014-x
  • dc.identifier.issn 1569-5794
  • dc.identifier.uri http://hdl.handle.net/10230/36998
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof The International Journal of Cardiovascular Imaging. 2017 March:33(3):331-9.
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/DEP2011-2013
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/DEP2010-20565
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DEP2013-44923-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
  • dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s10554-016-1014-x
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Right ventricle remodelling
  • dc.subject.keyword Athlete’s heart
  • dc.subject.keyword Overload
  • dc.title Characterizing the spectrum of right ventricular remodelling in response to chronic training
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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