Fruit and vegetable consumption is inversely associated with plasma saturated fatty acids at baseline in Predimed Plus Trial

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• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Castañer, Olga
• dc.contributor.author Malcampo, Mireia
• dc.contributor.author Lamuela-Raventós, Rosa M.
• dc.date.accessioned 2022-06-23T06:33:57Z
• dc.date.available 2022-06-23T06:33:57Z
• dc.date.issued 2022
• dc.description.abstract Scope: Plasma fatty acids (FAs) are associated with the development of cardiovascular diseases and metabolic syndrome. The aim of our study is to assess the relationship between fruit and vegetable (F&V) consumption and plasma FAs and their subtypes. Methods and results: Plasma FAs are assessed in a cross-sectional analysis of a subsample of 240 subjects from the PREDIMED-Plus study. Participants are categorized into four groups of fruit, vegetable, and fat intake according to the food frequency questionnaire. Plasma FA analysis is performed using gas chromatography. Associations between FAs and F&V consumption are adjusted for age, sex, physical activity, body mass index (BMI), total energy intake, and alcohol consumption. Plasma saturated FAs are lower in groups with high F&V consumption (-1.20 mg cL-1 [95% CI: [-2.22, -0.18], p-value = 0.021), especially when fat intake is high (-1.74 mg cL-1 [95% CI: [-3.41, -0.06], p-value = 0.042). Total FAs and n-6 polyunsaturated FAs tend to be lower in high consumers of F&V only in the high-fat intake groups. Conclusions: F&V consumption is associated with lower plasma saturated FAs when fat intake is high. These findings suggest that F&V consumption may have different associations with plasma FAs depending on their subtype and on the extent of fat intake.
• dc.description.sponsorship I.D.-L. is supported by the [FI_B 00256] from the FI-AGAUR Research Fellowship Program, Generalitat de Catalunya and M.M.-M is supported by the FPU17/00513 grant. Á.-H. is supported by the [CD17/00122] grant and S.K.N. is supported by a Canadian Institutes of Health Research (CIHR) Fellowship. We also thank all the volunteers for their participation in and the personnel for their contribution to the PREDIMED-Plus trial. This research was funded by CiCYT [AGL2016-75329-R] and CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER, UE), Generalitat de Catalunya (GC) [2017SGR196]. The PREDIMED-Plus trial was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated Fondo de Investigaciones Sanitarias projects lead by J.S.-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926 and PI19/00781), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, Fundació la Marató de TV3 (PI044003), 2017 SGR 1717 from Generalitat de Catalunya, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03 and CB12/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts. J.K. was supported by the “FOLIUM” program within the FUTURMed project entitled Talent for the medicine within the future from the Fundació Institut d'Investigació Sanitària Illes Balears. This call was co-financed at 50% with charge to the Operational Program FSE 2014–2020 of the Balearic Islands. This work is partially supported by ICREA under the ICREA Academia programme to J.S.-S.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-López I, Marhuenda-Muñoz M, Tresserra-Rimbau A, Hernáez Á, Moreno JJ, Martínez-González MÁ et al. Fruit and vegetable consumption is inversely associated with plasma saturated fatty acids at baseline in Predimed Plus Trial. Mol Nutr Food Res. 2021 Sep;65(17):e2100363. DOI: 10.1002/mnfr.202100363
• dc.identifier.doi http://dx.doi.org/10.1002/mnfr.202100363
• dc.identifier.issn 1613-4125
• dc.identifier.uri http://hdl.handle.net/10230/53572
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Mol Nutr Food Res. 2021 Sep;65(17):e2100363
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-R
• dc.rights © 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword MUFA
• dc.subject.keyword PREDIMED-Plus
• dc.subject.keyword PUFA
• dc.subject.keyword Dietary fats
• dc.subject.keyword Mediterranean diet
• dc.title Fruit and vegetable consumption is inversely associated with plasma saturated fatty acids at baseline in Predimed Plus Trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion