Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents

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• dc.contributor.author Dries, Michiel A. van den
• dc.contributor.author Lamballais, Sander
• dc.contributor.author El Marroun, Hanan
• dc.contributor.author Pronk, Anjoeka
• dc.contributor.author Spaan, Suzanne
• dc.contributor.author Ferguson, Kelly K.
• dc.contributor.author Longnecker, Matthew P.
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2021-04-21T11:00:17Z
• dc.date.issued 2020
• dc.description.abstract Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine repeatedly measured during gestation are associated with brain morphology and white matter microstructure in 518 preadolescents aged 9-12 years. Method: Data came from 518 mother-child pairs participating in the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands. Maternal urine concentrations were determined for 6 dialkylphosphates (DAPs) including 3 dimethyl (DM) and 3 diethyl (DE) alkyl phosphate metabolites, collected at early, mid, and late pregnancy. At child's age 9-12 years, magnetic resonance imaging was performed to obtain T1-weighted images for brain volumes and surface-based cortical thickness and cortical surface area, and diffusion tensor imaging was used to measure white matter microstructure through fractional anisotropy (FA) and mean diffusivity (MD). Linear regression models were fit for the averaged prenatal exposure across pregnancy. Results: DM and DE metabolite concentrations were not associated with brain volumes, cortical thickness, and cortical surface area. However, a 10-fold increase in averaged DM metabolite concentrations across pregnancy was associated with lower FA (B = -1.00, 95%CI = -1.80, -0.20) and higher MD (B = 0.13, 95%CI = 0.04, 0.21). Similar associations were observed for DE concentrations. Conclusions: This study provides the first evidence that OP pesticides may alter normal white matter microstructure in children, which could have consequences for normal neurodevelopment. No associations were observed with structural brain morphology, including brain volumes, cortical thickness, and cortical surface area.
• dc.description.sponsorship This research received financial support from the intramural research program of the National Institute of Environmental Health Sciences, National Institutes of Health (Grant# HHSN273201500003C). Neuroimaging was supported by the ZonMw TOP project no. 91211021. Henning Tiemeier was supported by a grant of the Netherlands Organization for Scientific Research (NWO grant No. 024.001.003, Consortium on Individual Development, and NWO/ ZonMW grant 016.VICI.170.200). Mònica Guxens is funded by a Miguel Servet fellowship (MS13/00054, CPII18/00018) awarded by the Spanish Institute of Health Carlos III. Monica Guxens acknowledges support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Programme. Dr. Hanan El Marroun was supported by Stichting Volksbond Rotterdam, the Dutch Brain Foundation (De Hersenstichting, project number GH2016.2.01) and the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 733206 LifeCycle)
• dc.format.mimetype application/pdf
• dc.identifier.citation Van den Dries MA, Lamballais S, El Marroun H, Pronk A, Spaan S, Ferguson KK et al. Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents. Environ Res. 2020 Dec;191:110047. DOI: 10.1016/j.envres.2020.110047
• dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2020.110047
• dc.identifier.issn 0013-9351
• dc.identifier.uri http://hdl.handle.net/10230/47180
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.envres.2020.110047
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Cervell -- Morfologia
• dc.subject.other Plaguicides
• dc.subject.other Embaràs
• dc.title Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion