Turbulent-like dynamics in the human brain

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• dc.contributor.author Deco, Gustavo
• dc.contributor.author Kringelbach, Morten L.
• dc.date.accessioned 2021-03-19T09:46:08Z
• dc.date.available 2021-03-19T09:46:08Z
• dc.date.issued 2020
• dc.description.abstract Turbulence facilitates fast energy/information transfer across scales in physical systems. These qualities are important for brain function, but it is currently unknown if the dynamic intrinsic backbone of the brain also exhibits turbulence. Using large-scale neuroimaging empirical data from 1,003 healthy participants, we demonstrate turbulent-like human brain dynamics. Furthermore, we build a whole-brain model with coupled oscillators to demonstrate that the best fit to the data corresponds to a region of maximally developed turbulent-like dynamics, which also corresponds to maximal sensitivity to the processing of external stimulations (information capability). The model shows the economy of anatomy by following the exponential distance rule of anatomical connections as a cost-of-wiring principle. This establishes a firm link between turbulent-like brain activity and optimal brain function. Overall, our results reveal a way of analyzing and modeling whole-brain dynamics that suggests a turbulent-like dynamic intrinsic backbone facilitating large-scale network communication.
• dc.description.sponsorship G.D. is supported by the Spanish Research Project (ref. PID2019-105772GBI00 AEI FEDER EU), funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI), and European Regional Development Funds (FEDER); and HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship program and SGR Research Support Group support (ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR). M.L.K. is supported by the ERC Consolidator grant CAREGIVING (no. 615539); Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117); and Centre for Eudaimonia and Human Flourishing, funded by the Pettit and Carlsberg Foundations.
• dc.format.mimetype application/pdf
• dc.identifier.citation Deco G, Kringelbach ML. Turbulent-like dynamics in the human brain. Cell Rep. 2020 Dec 8;33(10):108471. DOI: 10.1016/j.celrep.2020.108471
• dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2020.108471
• dc.identifier.issn 2211-1247
• dc.identifier.uri http://hdl.handle.net/10230/46862
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Cell Rep. 2020 Dec 8;33(10):108471
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772-GB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.rights © 2020 The Authors. This is an open access article under the CC BY-NC-ND license http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Whole-brain modelling
• dc.subject.keyword Anatomy
• dc.subject.keyword Exponential distance rule
• dc.subject.keyword Resting state
• dc.subject.keyword fMRI
• dc.subject.keyword dMRI
• dc.subject.keyword Turbulence-like dynamics
• dc.title Turbulent-like dynamics in the human brain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion