Rare long-range cortical connections enhance human information processing

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Deco, Gustavo
• dc.contributor.author Sanz Perl, Yonatan
• dc.contributor.author Vuust, Peter
• dc.contributor.author Tagliazucchi, Enzo
• dc.contributor.author Kennedy, Henry
• dc.date.accessioned 2023-02-16T07:06:26Z
• dc.date.available 2023-02-16T07:06:26Z
• dc.date.issued 2021
• dc.description.abstract What are the key topological features of connectivity critically relevant for generating the dynamics underlying efficient cortical function? A candidate feature that has recently emerged is that the connectivity of the mammalian cortex follows an exponential distance rule, which includes a small proportion of long-range high-weight anatomical exceptions to this rule. Whole-brain modeling of large-scale human neuroimaging data in 1,003 participants offers the unique opportunity to create two models, with and without long-range exceptions, and explicitly study their functional consequences. We found that rare long-range exceptions are crucial for significantly improving information processing. Furthermore, modeling in a simplified ring architecture shows that this improvement is greatly enhanced by the turbulent regime found in empirical neuroimaging data. Overall, the results provide strong empirical evidence for the immense functional benefits of long-range exceptions combined with turbulence for information processing.
• dc.description.sponsorship G.D. is supported by a Spanish national research project (reference PID2019-105772GB-I00 MCIU AEI), funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI); HBP SGA3 Human Brain Project Specific grant agreement 3 (grant agreement 945539), funded by the EU H2020 FET Flagship program; SGR Research Support Group (reference 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR); Neurotwin Digital twins for model-driven non-invasive electrical brain stimulation (grant agreement 101017716), funded by the EU H2020 FET Proactive program; euSNN European School of Network Neuroscience (grant agreement 860563), funded by the EU H2020 MSCA-ITN Innovative Training Networks; The Emerging Human Brain Cluster (CECH) (001-P-001682) within the framework of the European Research Development Fund Operational Program of Catalonia 2014–2020; Brain-Connects: Brain Connectivity during Stroke Recovery and Rehabilitation (201725.33), funded by the Fundacio La Marato TV3; and Corticity, FLAG-ERA JTC 2017 (reference PCI2018-092891), funded by the MCIU, AEI. M.L.K. is supported by the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and the Centre for Eudaimonia and Human Flourishing, funded by the Pettit Foundation and Carlsberg Foundation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Deco G, Sanz Perl Y, Vuust P, Tagliazucchi E, Kennedy H, Kringelbach ML. Rare long-range cortical connections enhance human information processing. Curr Biol. 2021;31(20):4436-48. DOI: 10.1016/j.cub.2021.07.064
• dc.identifier.doi http://dx.doi.org/10.1016/j.cub.2021.07.064
• dc.identifier.issn 0960-9822
• dc.identifier.uri http://hdl.handle.net/10230/55797
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Current Biology. 2021;31(20):4436-48.
• dc.relation.isreferencedby https://www.humanconnectome.org/study/hcp-young-adult
• dc.relation.isreferencedby https://github.com/decolab/cb-longrange
• dc.relation.isreferencedby https://www.cell.com/cms/10.1016/j.cub.2021.07.064/attachment/b58e1c8a-2ed0-4490-8095-974ee064e32e/mmc1.pdf
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101017716
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/860563
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.cub.2021.07.064
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword functional MRI
• dc.subject.keyword diffusion MRI
• dc.subject.keyword long-range exceptions
• dc.subject.keyword whole-brain modeling
• dc.subject.keyword turbulence
• dc.title Rare long-range cortical connections enhance human information processing
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion