Navigating pubertal goldilocks: the optimal pace for hierarchical brain organization
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- dc.contributor.author Szakács, Hanna
- dc.contributor.author Mutlu, Murat Can
- dc.contributor.author Balestrieri, Giulio
- dc.contributor.author Gombos, Ferenc
- dc.contributor.author Braun, Jochen
- dc.contributor.author Kringelbach, Morten L.
- dc.contributor.author Deco, Gustavo
- dc.contributor.author Kovács, Ilona
- dc.date.accessioned 2025-05-14T06:07:42Z
- dc.date.available 2025-05-14T06:07:42Z
- dc.date.issued 2024
- dc.description.abstract Adolescence is a timed process with an onset, tempo, and duration. Nevertheless, the temporal dimension, especially the pace of maturation, remains an insufficiently studied aspect of developmental progression. The primary objective is to estimate the precise influence of pubertal maturational tempo on the configuration of associative brain regions. To this end, the connection between maturational stages and the level of hierarchical organization of large-scale brain networks in 12-13-year-old females is analyzed. Skeletal maturity is used as a proxy for pubertal progress. The degree of maturity is defined by the difference between bone age and chronological age. To assess the level of hierarchical organization in the brain, the temporal dynamic of closed eye resting state high-density electroencephalography (EEG) in the alpha frequency range is analyzed. Different levels of hierarchical order are captured by the measured asymmetry in the directionality of information flow between different regions. The calculated EEG-based entropy production of participant groups is then compared with accelerated, average, and decelerated maturity. Results indicate that an average maturational trajectory optimally aligns with cerebral hierarchical order, and both accelerated and decelerated timelines result in diminished cortical organization. This suggests that a “Goldilocks rule” of brain development is favoring a particular maturational tempo.
- dc.format.mimetype application/pdf
- dc.identifier.citation Szakács H, Mutlu MC, Balestrieri G, Gombos F, Braun J, Deco G, et al. Navigating pubertal goldilocks: the optimal pace for hierarchical brain organization. Adv Sci. 2024 Jun 5;11(21):2308364. DOI: 10.1002/advs.202308364
- dc.identifier.doi http://dx.doi.org/10.1002/advs.202308364
- dc.identifier.issn 2198-3844
- dc.identifier.uri http://hdl.handle.net/10230/70388
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Advanced Science. 2024 Jun 5;11(21):2308364
- dc.rights © 2024 The Authors. Advanced Science published by Wiley-VCH GmbH.This is an open access article under the terms of the Creative CommonsAttribution License, which permits use, distribution and reproduction inany medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword One age
- dc.subject.keyword Brain development
- dc.subject.keyword Electrophysiology
- dc.subject.keyword Entropy production
- dc.subject.keyword Thermodynamics
- dc.title Navigating pubertal goldilocks: the optimal pace for hierarchical brain organization
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion