Pathway and network analysis of cancer genomes

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• dc.contributor.author Creixell, Pau
• dc.contributor.author Gonzalez-Perez, Abel
• dc.contributor.author López Bigas, Núria
• dc.contributor.author Mutation Consequences and Pathway Analysis Working Group of the International Cancer Genome Consortium
• dc.date.accessioned 2019-01-16T08:22:36Z
• dc.date.available 2019-01-16T08:22:36Z
• dc.date.issued 2015
• dc.description.abstract Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations.
• dc.description.sponsorship J.M.S. acknowledges support from the US National Cancer Institute (R01-CA180778 and U24-CA143858). L.D.S. and G.W. acknowledge support from the US National Institutes of Health (NIH) and National Human Genome Research Institute (P41 HG003751). G.D.B. is supported by NRNB (NIH, National Institute of General Medical Sciences grant number P41 GM103504)
• dc.format.mimetype application/pdf
• dc.identifier.citation Creixell P, Reimand J, Haider S, Wu G, Shibata T, Vazquez M et al. Pathway and network analysis of cancer genomes. Nat Methods. 2015 Jul;12(7):615-21. DOI: 10.1038/nmeth.3440
• dc.identifier.doi http://dx.doi.org/10.1038/nmeth.3440
• dc.identifier.issn 1548-7091
• dc.identifier.uri http://hdl.handle.net/10230/36284
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Methods. 2015 Jul;12(7):615-21
• dc.rights © Springer Nature Publishing AG. Creixell P, Reimand J, Haider S, Wu G, Shibata T, Vazquez M. Pathway and network analysis of cancer genomes. Nat Methods. 2015 Jul; 12(7): 615-621. http://dx.doi.org/10.1038/nmeth.3440
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Genètica
• dc.subject.other Genomes
• dc.subject.other Tumors -- Genètica
• dc.title Pathway and network analysis of cancer genomes
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion