Pathway and network analysis of cancer genomes

Creixell, Pau; Gonzalez-Perez, Abel; López Bigas, Núria; Mutation Consequences and Pathway Analysis Working Group of the International Cancer Genome Consortium

doi:http://dx.doi.org/10.1038/nmeth.3440

Pathway and network analysis of cancer genomes

Citation

Creixell P, Reimand J, Haider S, Wu G, Shibata T, Vazquez M et al. Pathway and network analysis of cancer genomes. Nat Methods. 2015 Jul;12(7):615-21. DOI: 10.1038/nmeth.3440

Abstract

Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations.