A signature of attractor dynamics in the CA3 region of the hippocampus

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• dc.contributor.author Rennó Costa, Césarca
• dc.contributor.author Lisman, John E.ca
• dc.contributor.author Verschure, Paul F. M. J.ca
• dc.date.accessioned 2016-02-16T17:35:06Z
• dc.date.available 2016-02-16T17:35:06Z
• dc.date.issued 2014
• dc.description.abstract The notion of attractor networks is the leading hypothesis for how associative memories are stored and recalled. A defining/nanatomical feature of such networks is excitatory recurrent connections. These ‘‘attract’’ the firing pattern of the network to/na stored pattern, even when the external input is incomplete (pattern completion). The CA3 region of the hippocampus has/nbeen postulated to be such an attractor network; however, the experimental evidence has been ambiguous, leading to the/nsuggestion that CA3 is not an attractor network. In order to resolve this controversy and to better understand how CA3/nfunctions, we simulated CA3 and its input structures. In our simulation, we could reproduce critical experimental results and/nestablish the criteria for identifying attractor properties. Notably, under conditions in which there is continuous input, the/noutput should be ‘‘attracted’’ to a stored pattern. However, contrary to previous expectations, as a pattern is gradually/n‘‘morphed’’ from one stored pattern to another, a sharp transition between output patterns is not expected. The observed/nfiring patterns of CA3 meet these criteria and can be quantitatively accounted for by our model. Notably, as morphing/nproceeds, the activity pattern in the dentate gyrus changes; in contrast, the activity pattern in the downstream CA3 network/nis attracted to a stored pattern and thus undergoes little change. We furthermore show that other aspects of the observed/nfiring patterns can be explained by learning that occurs during behavioral testing. The CA3 thus displays both the learning/nand recall signatures of an attractor network. These observations, taken together with existing anatomical and behavioral/nevidence, make the strong case that CA3 constructs associative memories based on attractor dynamics.ca
• dc.description.sponsorship This study was supported by National Institutes of Health Awards R01DA027807 and R01MH102841, by the European Commission through the projects Goal-Leaders (FP7-ICT- 270108) and Experimental Functional Android Assistant (FP7-ICT- 270490), and by the Brazilian agency CAPES through the Science Without Borders program (CSF-BJT 040/2012). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Rennó Costa C. Lisman JE, Verschure P. A signature of attractor dynamics in the CA3 region of the hippocampus. PLoS Computational Biology. 2014;10(5):1-15. DOI:10.1371/journal.pcbi.1003641
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1003641
• dc.identifier.issn 1553-734X
• dc.identifier.uri http://hdl.handle.net/10230/25843
• dc.language.iso engca
• dc.publisher Public Library of Scienceca
• dc.relation.ispartof PLoS Computational Biology. 2014;10(5):1-15
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/270108
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/270490
• dc.rights © 2014 Rennó-Costa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.title A signature of attractor dynamics in the CA3 region of the hippocampusca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca