Sleep-like cortical dynamics during wakefulness and their network effects following brain injury

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• dc.contributor.author Massimini, Marcello
• dc.contributor.author Corbetta, Maurizio
• dc.contributor.author Sanchez-Vives, Maria V.
• dc.contributor.author Andrillon, Thomas
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Rosanova, Maria Teresa
• dc.contributor.author Sarasso, Simone
• dc.date.accessioned 2025-06-17T06:39:53Z
• dc.date.available 2025-06-17T06:39:53Z
• dc.date.issued 2024
• dc.description.abstract By connecting old and recent notions, different spatial scales, and research domains, we introduce a novel framework on the consequences of brain injury focusing on a key role of slow waves. We argue that the long-standing finding of EEG slow waves after brain injury reflects the intrusion of sleep-like cortical dynamics during wakefulness; we illustrate how these dynamics are generated and how they can lead to functional network disruption and behavioral impairment. Finally, we outline a scenario whereby post-injury slow waves can be modulated to reawaken parts of the brain that have fallen asleep to optimize rehabilitation strategies and promote recovery.
• dc.description.sponsorship The authors thank Dr. Ezequiel Mikulan, Dr. Silvia Casarotto, Dr. Andrea Pigorini, Dr. Simone Russo, and Dr. Pilleriin Sikka for their help and comments on the manuscript draft and illustrations. This work was financially supported by the following entities: ERC-2022-SYG Grant number 101071900 neurological mechanisms of injury and sleep-like cellular dynamics (NEMESIS); Italian National Recovery and Resilience Plan (NRRP), M4C2, funded by the European Union - NextGenerationEU (Project IR0000011, CUP B51E22000150006, “EBRAINS-Italy”); European Union’s Horizon 2020 Framework Program for Research and Innovation under the Specific Grant Agreement No.945539 (Human Brain Project SGA3); Tiny Blue Dot Foundation; Canadian Institute for Advanced Research (CIFAR), Canada; Italian Ministry for Universities and Research (PRIN 2022); Fondazione Regionale per la Ricerca Biomedica (Regione Lombardia), Project ERAPERMED2019–101, GA 779282; CORTICOMOD PID2020-112947RB-I00 financed by MCIN/ AEI /10.13039/501100011033; Fondazione Cassa di Risparmio di Padova e Rovigo (CARIPARO) Grant Agreement number 55403; Ministry of Health, Italy (RF-2008 −12366899) Brain connectivity measured with high-density electroencephalography: a novel neurodiagnostic tool for stroke- NEUROCONN; BIAL foundation grant (Grant Agreement number 361/18); H2020 European School of Network Neuroscience (euSNN); H2020 Visionary Nature Based Actions For Heath, Wellbeing & Resilience in Cities (VARCITIES); Ministry of Health Italy (RF-2019-12369300): Eye-movement dynamics during free viewing as biomarker for assessment of visuospatial functions and for closed-loop rehabilitation in stroke (EYEMOVINSTROKE); ERC-2023-STG: 101116748 - SleepingAwake.
• dc.format.mimetype application/pdf
• dc.identifier.citation Massimini M, Corbetta M, Sanchez-Vives MV, Andrillon T, Deco G, Rosanova M, et al. Sleep-like cortical dynamics during wakefulness and their network effects following brain injury. Nat Commun. 2024;15:7207. DOI: 10.1038/s41467-024-51586-1
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-024-51586-1
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/70698
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Communications. 2024;15:7207
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101071900
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-112947RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101116748
• dc.rights © The Author(s) 2024. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Trastorns de la cognició
• dc.subject.other Dany cerebral
• dc.subject.other Anàlisi de conducta
• dc.title Sleep-like cortical dynamics during wakefulness and their network effects following brain injury
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion