The Manifestation of individual differences in sensitivity to punishment during resting state is modulated by eye state

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  • dc.contributor.author Costumero, Víctor
  • dc.contributor.author Adrián Ventura, Jesús
  • dc.contributor.author Bueichekú, Elisenda
  • dc.contributor.author Miró Padilla, Anna
  • dc.contributor.author Palomar García, María Ángeles
  • dc.contributor.author Marin-Marin, Lidon
  • dc.contributor.author Villar Rodríguez, Esteban
  • dc.contributor.author Aguirre, Naiara
  • dc.contributor.author Barrós Loscertales, Alfonso
  • dc.contributor.author Ávila, César
  • dc.date.accessioned 2021-03-24T10:07:40Z
  • dc.date.issued 2021
  • dc.description.abstract Structural and functional neuroimaging studies have shown that brain areas associated with fear and anxiety (defensive system areas) are modulated by individual differences in sensitivity to punishment (SP). However, little is known about how SP is related to brain functional connectivity and the factors that modulate this relationship. In this study, we investigated whether a simple methodological manipulation, such as performing a resting state with eyes open or eyes closed, can modulate the manifestation of individual differences in SP. To this end, we performed an exploratory fMRI resting state study in which a group of participants (n = 88) performed a resting state with eyes closed and another group (n = 56) performed a resting state with eyes open. All participants completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire. Seed-based functional connectivity analyses were performed in the amygdala, hippocampus, and periaqueductal gray (PAG). Our results showed that the relationship between SP and left amygdala-precuneus and left hippocampus-precuneus functional connectivity was modulated by eye state. Moreover, in the eyes open group, SP was negatively related to the functional connectivity between the PAG and amygdala and between the PAG and left hippocampus, and it was positively related to the functional connectivity between the amygdala and hippocampus. Together, our results may suggest underlying differences in the connectivity between anxiety-related areas based on eye state, which in turn would affect the manifestation of individual differences in SP.
  • dc.description.sponsorship This work was supported by grants from Generalitat Valenciana (PROMETEO/2017/109) and Ministerio de Economía y Competitividad (PSI2016-78805-R) to C.A. Also, it was supported by a grant from Jaume I University (UJI-B2016-21) to A.B-L. Additionally, this work was supported by a pre-doctoral graduate program grant (National FPU to J.A-V, L.M-M, E.V-R and N.A) and a post-doctoral graduate program grant (Juan de la Cierva to V.C and postdoc-UJI to A.M-P and M-Á.P-G). Author E.B was funded by a post-doctoral grant from the "Generalitat Valenciana (2018 APOSTD)" and the "European Social Fund (Investing in your future)"
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Costumero V, Adrián-Ventura J, Bueichekú E, Miró-Padilla A, Palomar-García MÁ, Marin-Marin L, Villar-Rodríguez E, Aguirre N, Barrós-Loscertales A, Ávila C. The Manifestation of individual differences in sensitivity to punishment during resting state is modulated by eye state. Cogn Affect Behav Neurosci. 2021 Jan 12;21:144-55. DOI: 10.3758/s13415-020-00856-8
  • dc.identifier.doi http://dx.doi.org/10.3758/s13415-020-00856-8
  • dc.identifier.issn 1530-7026
  • dc.identifier.uri http://hdl.handle.net/10230/46924
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Cognitive, Affective, & Behavioral Neuroscience. 2021 Jan 12;21:144-55
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-78805-R
  • dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.3758/s13415-020-00856-8.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Sensitivity to punishment
  • dc.subject.keyword Anxiety
  • dc.subject.keyword Resting state
  • dc.subject.keyword Amygdala
  • dc.subject.keyword Hippocampus
  • dc.subject.keyword Eyes open/closed
  • dc.title The Manifestation of individual differences in sensitivity to punishment during resting state is modulated by eye state
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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