Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness
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- dc.contributor.author Panda, Rajanikant
- dc.contributor.author Thibaut, Aurore
- dc.contributor.author Lopez-Gonzalez, Ane
- dc.contributor.author Escrichs, Anira
- dc.contributor.author Bahri, Mohamed Ali
- dc.contributor.author Hillebrand, Arjan
- dc.contributor.author Deco, Gustavo
- dc.contributor.author Laureys, Steven
- dc.contributor.author Gosseries, Olivia
- dc.contributor.author Annen, Jitka
- dc.contributor.author Tewarie, Prejaas
- dc.date.accessioned 2023-03-06T07:33:32Z
- dc.date.available 2023-03-06T07:33:32Z
- dc.date.issued 2022
- dc.description.abstract Understanding recovery of consciousness and elucidating its underlying mechanism is believed to be crucial in the field of basic neuroscience and medicine. Ideas such as the global neuronal workspace (GNW) and the mesocircuit theory hypothesize that failure of recovery in conscious states coincide with loss of connectivity between subcortical and frontoparietal areas, a loss of the repertoire of functional networks states and metastable brain activation. We adopted a time-resolved functional connectivity framework to explore these ideas and assessed the repertoire of functional network states as a potential marker of consciousness and its potential ability to tell apart patients in the unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). In addition, the prediction of these functional network states by underlying hidden spatial patterns in the anatomical network, that is so-called eigenmodes, was supplemented as potential markers. By analysing time-resolved functional connectivity from functional MRI data, we demonstrated a reduction of metastability and functional network repertoire in UWS compared to MCS patients. This was expressed in terms of diminished dwell times and loss of nonstationarity in the default mode network and subcortical fronto-temporoparietal network in UWS compared to MCS patients. We further demonstrated that these findings co-occurred with a loss of dynamic interplay between structural eigenmodes and emerging time-resolved functional connectivity in UWS. These results are, amongst others, in support of the GNW theory and the mesocircuit hypothesis, underpinning the role of time-resolved thalamo-cortical connections and metastability in the recovery of consciousness.
- dc.format.mimetype application/pdf
- dc.identifier.citation Panda R, Thibaut A, Lopez-Gonzalez A, Escrichs A, Bahri MA, Hillebrand A, Deco G, Laureys S, Gosseries O, Annen J, Tewarie P. Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness. Elife. 2022;11:e77462. DOI: 10.7554/eLife.77462
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.77462
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/56055
- dc.language.iso eng
- dc.publisher eLife
- dc.relation.ispartof eLife. 2022;11:e77462.
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/778234
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PCI2018-092891
- dc.rights © Panda et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Computational and Systems Biology
- dc.subject.keyword disorders of consciousness
- dc.subject.keyword fMRI
- dc.subject.keyword eigenmodes
- dc.subject.keyword dynamic connectivity
- dc.subject.keyword mesocircuit
- dc.subject.keyword global neuronal workspace
- dc.title Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion