MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays

Rubin, Alan F.; Dias, Mafalda; Frazer, Jonathan; Fowler, Douglas M.

doi:http://dx.doi.org/10.1186/s13059-025-03476-y

MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays

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Rubin AF, Stone J, Bianchi AH, Capodanno BJ, Da EY, Dias M, et al. MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays. Genome Biol. 2025 Jan 21;26(1):13. DOI: 10.1186/s13059-025-03476-y

Abstract

Multiplexed assays of variant effect (MAVEs) are a critical tool for researchers and clinicians to understand genetic variants. Here we describe the 2024 update to MaveDB ( https://www.mavedb.org/ ) with four key improvements to the MAVE community's database of record: more available data including over 7 million variant effect measurements, an improved data model supporting assays such as saturation genome editing, new built-in exploration and visualization tools, and powerful APIs for data federation and streamlined submission and access. Together these changes support MaveDB's role as a hub for the analysis and dissemination of MAVEs now and into the future.