Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Hernández Rubio, Anna; Sanvisens, Arantza; Barbier-Torres, Lucía; Blanes, Rafael; Miquel, Laia; Torrens, Marta; Rubio, Gabriel; Bolao, Ferran; Zuluaga, Paola; Fuster, Daniel; Rodríguez de Fonseca, Fernando; Farré Albaladejo, Magí; Muga, Roberto; CohRTA Study

Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

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dc.contributor.author Hernández Rubio, Anna
dc.contributor.author Sanvisens, Arantza
dc.contributor.author Barbier-Torres, Lucía
dc.contributor.author Blanes, Rafael
dc.contributor.author Miquel, Laia
dc.contributor.author Torrens, Marta
dc.contributor.author Rubio, Gabriel
dc.contributor.author Bolao, Ferran
dc.contributor.author Zuluaga, Paola
dc.contributor.author Fuster, Daniel
dc.contributor.author Rodríguez de Fonseca, Fernando
dc.contributor.author Farré Albaladejo, Magí
dc.contributor.author Muga, Roberto
dc.contributor.author CohRTA Study
dc.date.accessioned 2024-05-02T07:13:39Z
dc.date.available 2024-05-02T07:13:39Z
dc.date.issued 2023
dc.description.abstract Introduction Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD. Patients and Methods Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission. Results 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41–56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3–23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0–26.2) were the only factors associated with hypoMg. Conclusions Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.
dc.format.mimetype application/pdf
dc.identifier.citation Hernández-Rubio A, Sanvisens A, Barbier-Torres L, Blanes R, Miquel L, Torrens M, et al. Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder. Drug Alcohol Depend. 2023 Apr 1;245:109822. DOI: 10.1016/j.drugalcdep.2023.109822
dc.identifier.doi http://dx.doi.org/10.1016/j.drugalcdep.2023.109822
dc.identifier.issn 0376-8716
dc.identifier.uri http://hdl.handle.net/10230/59971
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Drug Alcohol Depend. 2023 Apr 1;245:109822
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Alcohol use disorder
dc.subject.keyword Electrolyte disturbances
dc.subject.keyword Magnesium deficiency
dc.subject.keyword Oxidative stress
dc.title Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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