Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Hernández Rubio, Anna; Sanvisens, Arantza; Barbier-Torres, Lucía; Blanes, Rafael; Miquel, Laia; Torrens, Marta; Rubio, Gabriel; Bolao, Ferran; Zuluaga, Paola; Fuster, Daniel; Rodríguez de Fonseca, Fernando; Farré Albaladejo, Magí; Muga, Roberto; CohRTA Study

doi:http://dx.doi.org/10.1016/j.drugalcdep.2023.109822

Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

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Hernández-Rubio A, Sanvisens A, Barbier-Torres L, Blanes R, Miquel L, Torrens M, et al. Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder. Drug Alcohol Depend. 2023 Apr 1;245:109822. DOI: 10.1016/j.drugalcdep.2023.109822

Abstract

Introduction Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD. Patients and Methods Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission. Results 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41–56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3–23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0–26.2) were the only factors associated with hypoMg. Conclusions Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.