Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis

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• dc.contributor.author de Jesús-Gil, Carmen
• dc.contributor.author Sans-de San Nicolás, Lídia
• dc.contributor.author Ruiz-Romeu, Ester
• dc.contributor.author Ferran Farrés, Marta
• dc.contributor.author Soria-Martinez, Laura
• dc.contributor.author García Jiménez, Irene
• dc.contributor.author Chiriac, Anca
• dc.contributor.author Casanova Seuma, Josep Manel
• dc.contributor.author Fernández Armenteros, José Manuel
• dc.contributor.author Owens, Sherry
• dc.contributor.author Celada, Antonio
• dc.contributor.author Howell, Michael D.
• dc.contributor.author Pujol Vallverdú, Ramon Maria
• dc.contributor.author Santamaría-Babí, Luis Francisco
• dc.date.accessioned 2021-06-22T06:52:28Z
• dc.date.available 2021-06-22T06:52:28Z
• dc.date.issued 2021
• dc.description.abstract Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA- cutaneous lymphocyte antigen (CLA)+/- T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA+ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA+ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients.
• dc.format.mimetype application/pdf
• dc.identifier.citation de Jesús-Gil C, Sans-de San Nicolàs L, Ruiz-Romeu E, Ferran M, Soria-Martínez L, García-Jiménez I, Chiriac A, Casanova-Seuma JM, Fernández-Armenteros JM, Owens S, Celada A, Howell MD, Pujol RM, Santamaria-Babí LF. Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis. Int J Mol Sci. 2021;22(4):1519. DOI: 10.3390/ijms22041519
• dc.identifier.doi http://dx.doi.org/10.3390/ijms22041519
• dc.identifier.issn 1422-0067
• dc.identifier.uri http://hdl.handle.net/10230/47957
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Int J Mol Sci. 2021;22(4):1519
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword CLA
• dc.subject.keyword Candida albicans
• dc.subject.keyword IL-17
• dc.subject.keyword IgA
• dc.subject.keyword Psoriasis
• dc.title Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion