Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis

de Jesús-Gil, Carmen; Sans-de San Nicolás, Lídia; Ruiz-Romeu, Ester; Ferran Farrés, Marta; Soria-Martinez, Laura; García-Jiménez, Irene; Chiriac, Anca; Casanova Seuma, Josep Manel; Fernández Armenteros, José Manuel; Owens, Sherry; Celada, Antonio; Howell, Michael D.; Pujol Vallverdú, Ramón M.; Santamaría-Babí, Luis Francisco

doi:http://dx.doi.org/10.3390/ijms22041519

Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis

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de Jesús-Gil C, Sans-de San Nicolàs L, Ruiz-Romeu E, Ferran M, Soria-Martínez L, García-Jiménez I, Chiriac A, Casanova-Seuma JM, Fernández-Armenteros JM, Owens S, Celada A, Howell MD, Pujol RM, Santamaria-Babí LF. Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis. Int J Mol Sci. 2021;22(4):1519. DOI: 10.3390/ijms22041519

Abstract

Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA- cutaneous lymphocyte antigen (CLA)+/- T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA+ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA+ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients.