Sustained and transient gray matter volume changes after n-back training: A VBM study

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• dc.contributor.author Miró Padilla, Anna
• dc.contributor.author Bueichekú, Elisenda
• dc.contributor.author Adrián Ventura, Jesús
• dc.contributor.author Costumero, Víctor
• dc.contributor.author Palomar García, María Ángeles
• dc.contributor.author Villar Rodríguez, Esteban
• dc.contributor.author Marin-Marin, Lidon
• dc.contributor.author Aguirre, Naiara
• dc.contributor.author Ávila, César
• dc.date.accessioned 2021-04-12T07:37:48Z
• dc.date.issued 2021
• dc.description.abstract Working memory training causes functional adaptations in the brain, which include changes in activation and functional connectivity that remain stable over time. Few studies have investigated gray matter (GM) changes after working memory training, and they have produced heterogeneous results without clarifying the stable effects of training. The present study was designed to test for sustained and transient anatomic changes after only 200 min of working memory training. The voxel-based morphometry technique was used in order to investigate the GM changes produced by a brief single n-back training, immediately and 5 weeks after finishing it. The sample was composed by 59 human participants who underwent MRI scanning and were assigned to either a training group or a passive control group. Results showed sustained GM volume enlargement in the right superior parietal cortex and a transient GM decrease in the right putamen. The brain adaptation in the right superior parietal cortex was stronger in individuals who showed greater improvements in performance. The results provide further evidence that a brief working memory training is able to produce brain plasticity in structures related to the trained task.
• dc.description.sponsorship This work was supported by grants from Universitat Jaume I (P1•1B2013-63) and Ministerio de Economia y Competitividad (PSI2013-47504-R and PSI2016-78805-R). Authors J. Adrián-Ventura, E. Villar-Rodriguez, L. Marin-Marin and N. Aguirre were supported by a pre-doctoral graduate program grant (National FPU to J.A-V, L.M-M, E.V-R and N.A). In addition, this work was supported by a post-doctoral graduate program grant to V. Costumero, M-Á. Palomar-García and A. Miró-Padilla (Juan de la Cierva to V.C and postdoc-UJI to M-Á.P-G and A.M.P). Author E. Bueichekú was funded by a postdoctoral grant from the "Generalitat Valenciana (2018 APOSTD)" and the "European Social Fund (Investing in your future)".
• dc.format.mimetype application/pdf
• dc.identifier.citation Miró-Padilla A, Bueichekú E, Adrián-Ventura J, Costumero V, Palomar-García MA, Villar-Rodríguez E, Marin-Marin L, Aguirre N, Ávila C. Sustained and transient gray matter volume changes after n-back training: A VBM study. Neurobiol Learn Mem. 2021 Feb;178:107368. DOI: 10.1016/j.nlm.2020.107368
• dc.identifier.doi http://dx.doi.org/10.1016/j.nlm.2020.107368
• dc.identifier.issn 1074-7427
• dc.identifier.uri http://hdl.handle.net/10230/47088
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Neurobiology of Learning and Memory. 2021 Feb;178:107368
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2013-47504-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-78805-R
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.nlm.2020.107368
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Brain plasticity
• dc.subject.keyword CAT12
• dc.subject.keyword Gray matter changes
• dc.subject.keyword N-back
• dc.subject.keyword Voxel-based morphometry
• dc.subject.keyword Working memory training
• dc.title Sustained and transient gray matter volume changes after n-back training: A VBM study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion