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Articles (Departament de Ciències Experimentals i de la Salut)

Articles (Departament de Ciències Experimentals i de la Salut)

 

Articles de recerca, en accés obert, del Departament de Ciències Experimentals i de la Salut de la UPF.

Recent Submissions

  • Illouz, Tomer; Biragyn, Arya; Iulita, Maria Florencia; Flores-Aguilar, Lisi; Dierssen, Mara; De Toma, Ilario; Antonarakis, Stylianos E.; Yu, Eugene; Herault, Yann; Potier, Marie-Claude; Botté, Alexandra; Roper, Randall; Sredni, Benjamin; London, Jacqueline; Mobley, William; Strydom, Andre; Okun, Eitan (Frontiers, 2021)
    The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular ...
  • Lara-Chica, Maribel; Correa-Sáez, Alejandro; Jiménez-Izquierdo, Rafael; Garrido-Rodríguez, Martín; Ponce, Francisco J.; Moreno, Rita; Morrison, Kimberley; Di Vona, Chiara, 1981-; Arató, Krisztina, 1981-; Jiménez-Jiménez, Carla; Morrugares, Rosario; Schmitz, M. Lienhard; Luna, Susana de la; Vega, Laureano de la; Calzado, Marco A. (Nature Research, 2021)
    The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle progression that acts on the phosphorylation status of Cyclin-Cyclin-dependent kinase complexes, with an emergent role in the DNA damage ...
  • Gallego-Paüls, Marta; Hernández-Ferrer, Carles; Bustamante Pineda, Mariona; Basagaña Flores, Xavier; Barrera Gómez, Jose; Vives Usano, Marta, 1990-; Ruiz Arenas, Carlos, 1990-; Casas Sanahuja, Maribel; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Estivill, Xavier, 1955-; Urquiza, José M.; González, Juan Ramón; Vrijheid, Martine; Maitre, Léa (BioMed Central, 2021)
    Background: Multiple omics technologies are increasingly applied to detect early, subtle molecular responses to environmental stressors for future disease risk prevention. However, there is an urgent need for further ...
  • Herman, Emily K.; Najle, Sebastián R.; Dacks, Joel B. (BioMed Central, 2021)
    Background: The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material ...
  • Pryszcz, Leszek Piotr, 1985-; Novoa, Eva Maria (Oxford University Press, 2021)
    Motivation: DNA and RNA modifications can now be identified using Nanopore sequencing. However, we currently lack a flexible software to efficiently encode, store, analyze and visualize DNA and RNA modification data. ...
  • Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • Bover, Jordi; Molina, Pablo; Ureña-Torres, Pablo; Arenas Jiménez, María Dolores (Elsevier, 2020)
  • Vara, Covadonga; Paytuví Gallart, Andreu; Cuartero, Yasmina; Álvarez-González, Lucía; Marín-Gual, Laia; Garcia, Francisca; Florit-Sabater, Beatriu; Capilla, Laia; Sanchéz-Guillén, Rosa Ana; Sarrate, Zaida; Cigliano, Riccardo Aiese; Sanseverino, Walter; Searle, Jeremy B.; Ventura, Jacint; Martí Renom, Marc A.; Le Dily, François; Ruiz Herrera, Aurora (Nature Research, 2021)
    The spatial folding of chromosomes inside the nucleus has regulatory effects on gene expression, yet the impact of genome reshuffling on this organization remains unclear. Here, we take advantage of chromosome conformation ...
  • Buitrago, Diana; Labrador, Mireia; Arcon, Juan Pablo; Lema, Rafael; Flores, Oscar; Esteve-Codina, Anna; Blanc, Julie; Villegas, Núria; Bellido, David; Gut, Marta; Dans, Pablo D.; Heath, Simon; Gut, Ivo Glynne; Brun-Heath, Isabelle; Orozco, Modesto (Nature Research, 2021)
    Determining the effect of DNA methylation on chromatin structure and function in higher organisms is challenging due to the extreme complexity of epigenetic regulation. We studied a simpler model system, budding yeast, ...
  • Willis, Jesse R.; Saus Martínez, Ester; Iraola Guzman, Susana; Cabello-Yeves, Elena; Ksiezopolska, Ewa; Cozzuto, Luca; Bejarano, Luis A.; Andreu Somavilla, Núria; Alloza-Trabado, Miriam; Blanco, Andrea; Puig-Sola, Anna; Broglio, Elisabetta; Carolis, Carlo; Ponomarenko, Julia; Hecht, Jochen; Gabaldón Estevan, Juan Antonio, 1973- (Taylor & Francis, 2021)
    Introduction: Cystic fibrosis (CF) is an autosomal genetic disease, associated with the production of excessively thick mucosa and with life-threatening chronic lung infections. The microbiota of the oral cavity can act ...
  • Bisceglie, Lavinia; Hopp, Ann-Katrin; Gunasekera, Kapila; Wright, Roni H.G.; Le Dily, François; Vidal, Enrique; Dall'Agnese, Alessandra; Caputo, Luca; Nicoletti, Chiara; Puri, Pier Lorenzo; Beato, Miguel; Hottiger, Michael O. (Elsevier, 2021)
    While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts ...
  • Ramirez, Juanma; Prieto, Gorka; Olazabal-Herrero, Anne; Borràs, Eva; Fernandez-Vigo, Elvira; Alduntzin, Unai; Osinalde, Nerea; Beaskoetxea, Javier; Lectez, Benoit; Aloria, Kerman; Rodríguez, José Antonio; Paradela, Alberto; Sabidó Aguadé, Eduard, 1981-; Muñoz, Javier; Corrales, Fernando; Arizmendi, Jesús M.; Mayor, Ugo (MDPI, 2021)
    The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ...
  • Espeso Gil, Sergio, 1985-; Holik, Aliaksei Z.; Bonnin, Sarah; Jhanwar, Shalu, 1986-; Chandrasekaran, Sandhya; Pique Regi, Roger; Albaigès-Ràfols, Júlia; Maher, Michael; Permanyer, Jon; Irimia, Manuel; Friedländer, Marc R.; Pons Espinal, Meritxell, 1986-; Akbarian, Schahram; Dierssen, Mara; Maass, Philipp G.; Hor, Charlotte N.; Ossowski, Stephan (Frontiers, 2021)
    In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the ...
  • Esteve-Codina, Anna; Soler Artigas, María; Dabad, Marc; Fernández Callejo, Marcos; Griebel, Thasso; Heath, Simon; Gut, Ivo Glynne; Ziegler-Heitbrock, Loems (Nature Research, 2021)
    Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush ...
  • Guerrero-Cózar, Israel; Gómez-Garrido, Jèssica; Berbel, Concha; Martinez-Blanch, Juan F.; Alioto, Tyler; Claros, M. Gonzalo; Gagnaire, Pierre-Alexandre; Manchado, Manuel (Nature Research, 2021)
    The integration of physical and high-density genetic maps is a very useful approach to achieve chromosome-level genome assemblies. Here, the genome of a male Senegalese sole (Solea senegalensis) was de novo assembled and ...
  • Lang, Benjamin; Yang, Jae-Seong; Garriga-Canut, Mireia; Speroni, Silvia; Aschern, Moritz; Gili, Maria; Hoffmann, Tobias, 1990-; Tartaglia, Gian Gaetano; Maurer, Sebastian (Oxford University Press, 2021)
    RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, ...
  • Vilor Tejedor, Natàlia, 1988-; Evans, Tavia E.; Adams, Hieab H.; González de Echávarri, José Maria; Molinuevo, José Luis; Guigó Serra, Roderic; Gispert López, Juan Domingo; Operto, Grégory (Wolters Kluwer (LWW), 2021)
    There is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes ...
  • Bauer, Moritz, 1987-; Vidal, Enrique; Zorita, Eduard; Üresin, Nil; Pinter, Stefan F.; Filion, Guillaume; Payer, Bernhard, 1975- (Nature Research, 2021)
    A hallmark of chromosome organization is the partition into transcriptionally active A and repressed B compartments, and into topologically associating domains (TADs). Both structures were regarded to be absent from the ...
  • Suay-Corredera, Carmen; Pricolo, Maria Rosaria; Herrero-Galán, Elías; Velázquez-Carreras, Diana; Sánchez-Ortiz, David; García-Giustiniani, Diego; Delgado Blanco, Javier; Galano-Frutos, Juan José; García-Cebollada, Helena; Vilches, Silvia; Domínguez, Fernando; Sabater Molina, María; Barriales-Villa, Roberto; Frisso, Giulia; Sancho, Javier; Serrano Pubull, Luis, 1982-; García-Pavía, Pablo; Monserrat, Lorenzo; Alegre-Cebollada, Jorge (Elsevier, 2021)
    Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease. Variants in MYBPC3, the gene encoding cardiac myosin-binding protein C (cMyBP-C), are the leading cause of HCM. However, the pathogenicity ...
  • Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Stadhouders, Ralph; Di Stefano, Bruno, 1984-; Ribó Rubio, Anna; Berenguer, Clara; Generoso, Serena Francesca, 1988-; Mallol, Anna; Sardina, Jose Luis; Payer, Bernhard, 1975-; Graf, T. (Thomas); Valcárcel, J. (Juan) (BioMed Central, 2021)
    Background: Somatic cell reprogramming is the process that allows differentiated cells to revert to a pluripotent state. In contrast to the extensively studied rewiring of epigenetic and transcriptional programs required ...

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