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Cardiovascular risk protection from the Mediterranean diet and olive oil: a transcriptomic update in humans

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dc.contributor.author Carrión, Sílvia
dc.contributor.author Torres-Collado, Laura
dc.contributor.author Castañer, Olga
dc.date.accessioned 2023-11-21T06:53:36Z
dc.date.available 2023-11-21T06:53:36Z
dc.date.issued 2016
dc.identifier.citation Carrión S, Torres L, Castañer O. Cardiovascular risk protection from the Mediterranean diet and olive oil: a transcriptomic update in humans. Grasas y aceites. 2016 Dec 30;67(4):e161. DOI: 10.3989/gya.0451161
dc.identifier.issn 0017-3495
dc.identifier.uri http://hdl.handle.net/10230/58343
dc.description.abstract This review highlights the human studies that explore the benefits of the Mediterranean diet and olive oil, based on gene expression analysis. We summarized consistent human transcriptomic studies on cardiovascular risk, based on TMD and olive oil interventions, with real life doses and conditions. A literature review was carried out leading up to February 2016. The results show that the TMD, specially supplemented with virgin olive oil, produces beneficial changes in the transcriptomic response of relevant genes in cardiovascular risk such as CAT, GPX1 and SIRT2. p65 and MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 and IL7R, which are involved in inflammation; and ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 and COX-1, which play an important role in cholesterol efflux. The available data illustrate a transcriptomic effect on atherosclerosis, inflammation and oxidative stress pathways as well as the mentioned genes.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher CSIC
dc.relation.ispartof Grasas y aceites. 2016 Dec 30;67(4):e161
dc.rights © 2016 CSIC. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-by) Spain 3.0 License.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Cardiovascular risk protection from the Mediterranean diet and olive oil: a transcriptomic update in humans
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3989/gya.0451161
dc.subject.keyword Cardiovascular
dc.subject.keyword Mediterranean diet
dc.subject.keyword MUFA
dc.subject.keyword Nutrigenomics
dc.subject.keyword Olive oil
dc.subject.keyword Polyphenols
dc.subject.keyword Transcriptomics
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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