Cardiovascular risk protection from the Mediterranean diet and olive oil: a transcriptomic update in humans
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- dc.contributor.author Carrión, Sílvia
- dc.contributor.author Torres-Collado, Laura
- dc.contributor.author Castañer, Olga
- dc.date.accessioned 2023-11-21T06:53:36Z
- dc.date.available 2023-11-21T06:53:36Z
- dc.date.issued 2016
- dc.description.abstract This review highlights the human studies that explore the benefits of the Mediterranean diet and olive oil, based on gene expression analysis. We summarized consistent human transcriptomic studies on cardiovascular risk, based on TMD and olive oil interventions, with real life doses and conditions. A literature review was carried out leading up to February 2016. The results show that the TMD, specially supplemented with virgin olive oil, produces beneficial changes in the transcriptomic response of relevant genes in cardiovascular risk such as CAT, GPX1 and SIRT2. p65 and MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 and IL7R, which are involved in inflammation; and ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 and COX-1, which play an important role in cholesterol efflux. The available data illustrate a transcriptomic effect on atherosclerosis, inflammation and oxidative stress pathways as well as the mentioned genes.
- dc.format.mimetype application/pdf
- dc.identifier.citation Carrión S, Torres L, Castañer O. Cardiovascular risk protection from the Mediterranean diet and olive oil: a transcriptomic update in humans. Grasas y aceites. 2016 Dec 30;67(4):e161. DOI: 10.3989/gya.0451161
- dc.identifier.doi http://dx.doi.org/10.3989/gya.0451161
- dc.identifier.issn 0017-3495
- dc.identifier.uri http://hdl.handle.net/10230/58343
- dc.language.iso eng
- dc.publisher CSIC
- dc.relation.ispartof Grasas y aceites. 2016 Dec 30;67(4):e161
- dc.rights © 2016 CSIC. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-by) Spain 3.0 License.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cardiovascular
- dc.subject.keyword Mediterranean diet
- dc.subject.keyword MUFA
- dc.subject.keyword Nutrigenomics
- dc.subject.keyword Olive oil
- dc.subject.keyword Polyphenols
- dc.subject.keyword Transcriptomics
- dc.title Cardiovascular risk protection from the Mediterranean diet and olive oil: a transcriptomic update in humans
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion