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Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing

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dc.contributor.author Sarreshtehdari, Amirhossein
dc.contributor.author Burdío Pinilla, Fernando
dc.contributor.author López Alonso, Borja
dc.contributor.author Lucía, Óscar
dc.contributor.author Burdío, José M.
dc.contributor.author Villamonte, Maria
dc.contributor.author Andaluz, Anna
dc.contributor.author García Arnas, Félix
dc.contributor.author Berjano, Enrique J.
dc.contributor.author Moll, Xavier
dc.date.accessioned 2023-09-26T06:31:49Z
dc.date.available 2023-09-26T06:31:49Z
dc.date.issued 2023
dc.identifier.citation Sarreshtehdari A, Burdio F, López‑Alonso B, Lucía Ó, Burdio JM, Villamonte M, Andaluz A, García‑Arnas F, Berjano E, Moll X. Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing. Sci Rep. 2023;13:7120. DOI: 10.1038/s41598-023-33487-3
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/57957
dc.description.abstract Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0.008 mL/g for 16 min. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2.1, at 0.008 mL/g for 16 min. Group 2.2 at 0.03 mL/g for 4 min. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4.31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, impedance alteration by Glucose solution infusion may focus IRE on tumor tissue and decrease IRE's effects on healthy tissue.
dc.description.sponsorship This research was supported by the Spanish government (Ministry of Economy and Competitiveness) under Grants RTI2018-094357-B-C21, RTI2018-094357-B-C22 and Carlos III Health Institute under Grant PI17/0048 and also PI21/00440 from the same institution.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Sci Rep. 2023;13:7120
dc.rights © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41598-023-33487-3
dc.subject.keyword Cancer
dc.subject.keyword Diseases
dc.subject.keyword Health care
dc.subject.keyword Medical research
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C21
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C22
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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