Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing

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• dc.contributor.author Sarreshtehdari, Amirhossein
• dc.contributor.author Burdío Pinilla, Fernando
• dc.contributor.author López Alonso, Borja
• dc.contributor.author Lucía, Óscar
• dc.contributor.author Burdío, José M.
• dc.contributor.author Villamonte, Maria
• dc.contributor.author Andaluz, Anna
• dc.contributor.author García Arnas, Félix
• dc.contributor.author Berjano, Enrique J.
• dc.contributor.author Moll, Xavier
• dc.date.accessioned 2023-09-26T06:31:49Z
• dc.date.available 2023-09-26T06:31:49Z
• dc.date.issued 2023
• dc.description.abstract Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0.008 mL/g for 16 min. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2.1, at 0.008 mL/g for 16 min. Group 2.2 at 0.03 mL/g for 4 min. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4.31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, impedance alteration by Glucose solution infusion may focus IRE on tumor tissue and decrease IRE's effects on healthy tissue.
• dc.description.sponsorship This research was supported by the Spanish government (Ministry of Economy and Competitiveness) under Grants RTI2018-094357-B-C21, RTI2018-094357-B-C22 and Carlos III Health Institute under Grant PI17/0048 and also PI21/00440 from the same institution.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sarreshtehdari A, Burdio F, López‑Alonso B, Lucía Ó, Burdio JM, Villamonte M, Andaluz A, García‑Arnas F, Berjano E, Moll X. Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing. Sci Rep. 2023;13:7120. DOI: 10.1038/s41598-023-33487-3
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-023-33487-3
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/57957
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Sci Rep. 2023;13:7120
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C21
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C22
• dc.rights © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cancer
• dc.subject.keyword Diseases
• dc.subject.keyword Health care
• dc.subject.keyword Medical research
• dc.title Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion