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Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies

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dc.contributor.author Stratakis, Nikos
dc.contributor.author Rock, Sarah
dc.contributor.author La Merrill, Michele A.
dc.contributor.author Saez, Marc
dc.contributor.author Robinson, Oliver
dc.contributor.author Fecht, Daniela
dc.contributor.author Vrijheid, Martine
dc.contributor.author Valvi, Damaskini, 1983-
dc.contributor.author Conti, David V.
dc.contributor.author McConnell, Rob
dc.contributor.author Chatzi, Lida Vaia
dc.date.accessioned 2023-03-31T06:07:28Z
dc.date.available 2023-03-31T06:07:28Z
dc.date.issued 2022
dc.identifier.citation Stratakis N, Rock S, La Merrill MA, Saez M, Robinson O, Fecht D, Vrijheid M, Valvi D, Conti DV, McConnell R, Chatzi LV. Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies. Obes Rev. 2022 Jan;23 Suppl 1(Suppl 1):e13383. DOI: 10.1111/obr.13383
dc.identifier.issn 1467-7881
dc.identifier.uri http://hdl.handle.net/10230/56387
dc.description.abstract We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], and polychlorinated biphenyls [PCBs]), perfluoroalkyl and polyfluoroalkyl substances (PFAS), and polybrominated diphenyl ethers (PBDEs) that are the POPs more widely studied in environmental birth cohorts so far. We search two databases (PubMed and Embase) through July/09/2021 and identified 33 studies reporting associations with prenatal organochlorine exposure, 21 studies reporting associations with prenatal PFAS, and five studies reporting associations with prenatal PBDEs. We conducted a qualitative review. Additionally, we performed random-effects meta-analyses of POP exposures, with data estimates from at least three prospective studies, and BMI-z. Prenatal DDE and HCB levels were associated with higher BMI z-score in childhood (beta: 0.12, 95% CI: 0.03, 0.21; I2 : 28.1% per study-specific log increase of DDE and beta: 0.31, 95% CI: 0.09, 0.53; I2 : 31.9% per study-specific log increase of HCB). No significant associations between PCB-153, PFOA, PFOS, or pentaPBDEs with childhood BMI were found in meta-analyses. In individual studies, there was inconclusive evidence that POP levels were positively associated with other obesity indicators (e.g., waist circumference).
dc.description.sponsorship This study is an ancillary endeavor of the Science & Technology in childhood Obesity Policy (STOP) project (H2020 SC2; ref. 774548). This study was supported by the National Institute of Environmental Health Science (NIEHS, R01ES030364). Additional funding from NIEHS includes R21ES029681 (Chatzi, McConnell, Conti, Valvi, Stratakis), R01ES029944 (Chatzi, Conti, Valvi, Rock), R01ES030691 (Chatzi, McConnell, Conti, Valvi), R21ES028903 (Chatzi, McConnell, Valvi), P30ES007048 (McConnell, Chatzi, Conti, Stratakis), R21ES029328 (Valvi), and P30ES023515 (Valvi). Additional funding from NIH supported Dr. Conti (P01CA196569, R01CA140561, R01ES016813), and Dr. Stratakis (P30DK048522). Dr La Merill received additional funding from USDA National Institute of Food and Agriculture, Hatch project: 1002182.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Obes Rev. 2022 Jan;23 Suppl 1(Suppl 1):e13383
dc.rights This is the peer reviewed version of the following article: Stratakis N, Rock S, La Merrill MA, Saez M, Robinson O, Fecht D, Vrijheid M, Valvi D, Conti DV, McConnell R, Chatzi VL. Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies. Obes Rev. 2022 Jan;23 Suppl 1(Suppl 1):e13383. DOI: 10.1111/obr.13383, which has been published in final form at http://dx.doi.org/10.1111/obr.13383. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.title Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/obr.13383
dc.subject.keyword Childhood
dc.subject.keyword STOP project
dc.subject.keyword Obesity
dc.subject.keyword Persistent organic pollutants
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/774548
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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