Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Stratakis, Nikos
  • dc.contributor.author Rock, Sarah
  • dc.contributor.author La Merrill, Michele A.
  • dc.contributor.author Saez, Marc
  • dc.contributor.author Robinson, Oliver
  • dc.contributor.author Fecht, Daniela
  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Valvi, Damaskini, 1983-
  • dc.contributor.author Conti, David V.
  • dc.contributor.author McConnell, Rob
  • dc.contributor.author Chatzi, Lida Vaia
  • dc.date.accessioned 2023-03-31T06:07:28Z
  • dc.date.available 2023-03-31T06:07:28Z
  • dc.date.issued 2022
  • dc.description.abstract We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], and polychlorinated biphenyls [PCBs]), perfluoroalkyl and polyfluoroalkyl substances (PFAS), and polybrominated diphenyl ethers (PBDEs) that are the POPs more widely studied in environmental birth cohorts so far. We search two databases (PubMed and Embase) through July/09/2021 and identified 33 studies reporting associations with prenatal organochlorine exposure, 21 studies reporting associations with prenatal PFAS, and five studies reporting associations with prenatal PBDEs. We conducted a qualitative review. Additionally, we performed random-effects meta-analyses of POP exposures, with data estimates from at least three prospective studies, and BMI-z. Prenatal DDE and HCB levels were associated with higher BMI z-score in childhood (beta: 0.12, 95% CI: 0.03, 0.21; I2 : 28.1% per study-specific log increase of DDE and beta: 0.31, 95% CI: 0.09, 0.53; I2 : 31.9% per study-specific log increase of HCB). No significant associations between PCB-153, PFOA, PFOS, or pentaPBDEs with childhood BMI were found in meta-analyses. In individual studies, there was inconclusive evidence that POP levels were positively associated with other obesity indicators (e.g., waist circumference).
  • dc.description.sponsorship This study is an ancillary endeavor of the Science & Technology in childhood Obesity Policy (STOP) project (H2020 SC2; ref. 774548). This study was supported by the National Institute of Environmental Health Science (NIEHS, R01ES030364). Additional funding from NIEHS includes R21ES029681 (Chatzi, McConnell, Conti, Valvi, Stratakis), R01ES029944 (Chatzi, Conti, Valvi, Rock), R01ES030691 (Chatzi, McConnell, Conti, Valvi), R21ES028903 (Chatzi, McConnell, Valvi), P30ES007048 (McConnell, Chatzi, Conti, Stratakis), R21ES029328 (Valvi), and P30ES023515 (Valvi). Additional funding from NIH supported Dr. Conti (P01CA196569, R01CA140561, R01ES016813), and Dr. Stratakis (P30DK048522). Dr La Merill received additional funding from USDA National Institute of Food and Agriculture, Hatch project: 1002182.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Stratakis N, Rock S, La Merrill MA, Saez M, Robinson O, Fecht D, Vrijheid M, Valvi D, Conti DV, McConnell R, Chatzi LV. Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies. Obes Rev. 2022 Jan;23 Suppl 1(Suppl 1):e13383. DOI: 10.1111/obr.13383
  • dc.identifier.doi http://dx.doi.org/10.1111/obr.13383
  • dc.identifier.issn 1467-7881
  • dc.identifier.uri http://hdl.handle.net/10230/56387
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Obes Rev. 2022 Jan;23 Suppl 1(Suppl 1):e13383
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/774548
  • dc.rights This is the peer reviewed version of the following article: Stratakis N, Rock S, La Merrill MA, Saez M, Robinson O, Fecht D, Vrijheid M, Valvi D, Conti DV, McConnell R, Chatzi VL. Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies. Obes Rev. 2022 Jan;23 Suppl 1(Suppl 1):e13383. DOI: 10.1111/obr.13383, which has been published in final form at http://dx.doi.org/10.1111/obr.13383. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Childhood
  • dc.subject.keyword STOP project
  • dc.subject.keyword Obesity
  • dc.subject.keyword Persistent organic pollutants
  • dc.title Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)