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Gene structure evolution of the Short-Chain Dehydrogenase/Reductase (SDR) family

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dc.contributor.author Gabrielli, Franco
dc.contributor.author Antinucci, Marco
dc.contributor.author Tofanelli, Sergio
dc.date.accessioned 2023-03-21T07:09:08Z
dc.date.available 2023-03-21T07:09:08Z
dc.date.issued 2023
dc.identifier.citation Gabrielli F, Antinucci M, Tofanelli S. Gene structure evolution of the Short-Chain Dehydrogenase/Reductase (SDR) family. Genes. 2023 Jan;14(1):110. DOI: 10.3390/genes14010110
dc.identifier.issn 2073-4425
dc.identifier.uri http://hdl.handle.net/10230/56302
dc.description.abstract SDR (Short-chain Dehydrogenases/Reductases) are one of the oldest and heterogeneous superfamily of proteins, whose classification is problematic because of the low percent identity, even within families. To get clearer insights into SDR molecular evolution, we explored the splicing site organization of the 75 human SDR genes across their vertebrate and invertebrate orthologs. We found anomalous gene structures in members of the human SDR7C and SDR42E families that provide clues of retrogene properties and independent evolutionary trajectories from a common invertebrate ancestor. The same analyses revealed that the identity value between human and invertebrate non-allelic variants is not necessarily associated with the homologous gene structure. Accordingly, a revision of the SDR nomenclature is proposed by including the human SDR40C1 and SDR7C gene in the same family.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Genes. 2023 Jan;14(1):110
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Gene structure evolution of the Short-Chain Dehydrogenase/Reductase (SDR) family
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/genes14010110
dc.subject.keyword SDR-family
dc.subject.keyword Splicing sites
dc.subject.keyword Orthologous genes
dc.subject.keyword Genetic homology
dc.subject.keyword Retrogenes
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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