Gene structure evolution of the Short-Chain Dehydrogenase/Reductase (SDR) family

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• dc.contributor.author Gabrielli, Franco
• dc.contributor.author Antinucci, Marco
• dc.contributor.author Tofanelli, Sergio
• dc.date.accessioned 2023-03-21T07:09:08Z
• dc.date.available 2023-03-21T07:09:08Z
• dc.date.issued 2023
• dc.description.abstract SDR (Short-chain Dehydrogenases/Reductases) are one of the oldest and heterogeneous superfamily of proteins, whose classification is problematic because of the low percent identity, even within families. To get clearer insights into SDR molecular evolution, we explored the splicing site organization of the 75 human SDR genes across their vertebrate and invertebrate orthologs. We found anomalous gene structures in members of the human SDR7C and SDR42E families that provide clues of retrogene properties and independent evolutionary trajectories from a common invertebrate ancestor. The same analyses revealed that the identity value between human and invertebrate non-allelic variants is not necessarily associated with the homologous gene structure. Accordingly, a revision of the SDR nomenclature is proposed by including the human SDR40C1 and SDR7C gene in the same family.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gabrielli F, Antinucci M, Tofanelli S. Gene structure evolution of the Short-Chain Dehydrogenase/Reductase (SDR) family. Genes. 2023 Jan;14(1):110. DOI: 10.3390/genes14010110
• dc.identifier.doi http://dx.doi.org/10.3390/genes14010110
• dc.identifier.issn 2073-4425
• dc.identifier.uri http://hdl.handle.net/10230/56302
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Genes. 2023 Jan;14(1):110
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword SDR-family
• dc.subject.keyword Splicing sites
• dc.subject.keyword Orthologous genes
• dc.subject.keyword Genetic homology
• dc.subject.keyword Retrogenes
• dc.title Gene structure evolution of the Short-Chain Dehydrogenase/Reductase (SDR) family
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion