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The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation

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dc.contributor.author Rolls, Edmund T.
dc.contributor.author Wirth, Sylvia
dc.contributor.author Deco, Gustavo
dc.contributor.author Huang, Chu-Chung
dc.contributor.author Feng, Jianfeng
dc.date.accessioned 2023-03-13T07:43:04Z
dc.date.available 2023-03-13T07:43:04Z
dc.date.issued 2023
dc.identifier.citation Rolls ET, Wirth S, Deco G, Huang CC, Feng J. The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation. Human Brain Mapping. 2023 Feb 1;44(2):629-55. DOI: 10.1002/hbm.26089
dc.identifier.issn 1097-0193
dc.identifier.uri http://hdl.handle.net/10230/56177
dc.description Includes supplementary materials for the online appendix.
dc.description.abstract The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory and navigation. The functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of these Posterior Cingulate Division (PCD) regions in the Human Connectome Project-MMP1 atlas in 171 HCP participants, and complemented with functional connectivity and diffusion tractography. First, the postero-ventral parts of the PCD (31pd, 31pv, 7m, d23ab, and v23ab) have effective connectivity with the temporal pole, inferior temporal visual cortex, cortex in the superior temporal sulcus implicated in auditory and semantic processing, with the reward-related vmPFC and pregenual anterior cingulate cortex, with the inferior parietal cortex, and with the hippocampal system. This connectivity implicates it in hippocampal episodic memory, providing routes for “what,” reward and semantic schema-related information to access the hippocampus. Second, the antero-dorsal parts of the PCD (especially 31a and 23d, PCV, and also RSC) have connectivity with early visual cortical areas including those that represent spatial scenes, with the superior parietal cortex, with the pregenual anterior cingulate cortex, and with the hippocampal system. This connectivity implicates it in the “where” component for hippocampal episodic memory and for spatial navigation. The dorsal–transitional–visual (DVT) and ProStriate regions where the retrosplenial scene area is located have connectivity from early visual cortical areas to the parahippocampal scene area, providing a ventromedial route for spatial scene information to reach the hippocampus. These connectivities provide important routes for “what,” reward, and “where” scene-related information for human hippocampal episodic memory and navigation. The midcingulate cortex provides a route from the anterior dorsal parts of the PCD and the supracallosal part of the anterior cingulate cortex to premotor regions.
dc.description.sponsorship The research was supported by the following grants to Professor J. Feng: National Key R&D Program of China (No. 2019YFA0709502); 111 Project (No. B18015); Shanghai Municipal Science and Technology Major Project, ZJLab, and Shanghai Center for Brain Science and Brain-Inspired Technology (No. 2018SHZDZX01); and National Key R&D Program of China (No. 2018YFC1312904). G.D. is supported by a Spanish National Research Project funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) (ref. PID2019-105772GB-I00 MCIU AEI); HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme; SGR Research Support Group Support (ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR); Neurotwin Digital twins for model-driven non-invasive electrical brain stimulation (grant agreement ID: 101017716) funded by the EU H2020 FET Proactive Programme; euSNN European School of Network Neuroscience (grant agreement ID: 860563) funded by the EU H2020 MSCA-ITN Innovative Training Networks; CECH The Emerging Human Brain Cluster (Id. 001-P-001682) within the framework of the European Research Development Fund Operational Program of Catalonia 2014–2020; Brain-Connects: Brain Connectivity during Stroke Recovery and Rehabilitation (id. 201725.33) funded by the Fundacio La Marato TV3; Corticity, FLAG ERA JTC 2017, (ref. PCI2018-092891) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). The funding agencies played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Human Brain Mapping. 2023 Feb 1;44(2):629-55
dc.rights © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of theCreative Commons AttributionLicense, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/hbm.26089
dc.subject.keyword Hippocampus
dc.subject.keyword Memory
dc.subject.keyword Midcingulate cortex
dc.subject.keyword Navigation
dc.subject.keyword Posterior cingulate cortex
dc.subject.keyword Retrosplenial cortex
dc.subject.keyword Spatial view cells
dc.subject.keyword Visuo-motor coordinate transforms
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101017716
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/860563
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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