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Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial

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dc.contributor.author Farràs Mañé, Marta
dc.contributor.author Swann, Jonathan Richard
dc.contributor.author Rowland, Ian
dc.contributor.author Rubió, Laura
dc.contributor.author Subirana Cachinero, Isaac
dc.contributor.author Catalán, Úrsula
dc.contributor.author Motilva, Maria-José
dc.contributor.author Solà, Rosa
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Blanco-Vaca, Francisco
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Mayneris Perxachs, Jordi
dc.date.accessioned 2023-02-22T07:19:09Z
dc.date.available 2023-02-22T07:19:09Z
dc.date.issued 2022
dc.identifier.citation Farràs M, Swann JR, Rowland I, Rubió L, Subirana I, Catalán Ú, Motilva MJ, et al. Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial. Antioxidants (Basel). 2022 Sep 30; 11(10): 1964. DOI: 10.3390/antiox11101964
dc.identifier.issn 2076-3921
dc.identifier.uri http://hdl.handle.net/10230/55837
dc.description.abstract Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thirty-three hypercholesterolemic individuals who ingested for 3-weeks (25 mL/day): (1) an OO enriched with its own olive oil phenolic compounds (PCs) (500 ppm; FOO); (2) an OO enriched with its own olive oil PCs (250 ppm) plus thyme PCs (250 ppm; FOOT); and (3) a VOO with low phenolic content (80 ppm). Serum lipid and glycemic profiles, serum 1H-NMR spectroscopy-based metabolomics, endothelial function, blood pressure, and cardiovascular risk were measured. We combined OPLS-DA with machine learning modelling to identify metabolites discrimination of the treatment groups. Both phenol-enriched OO interventions decreased the levels of glutamine, creatinine, creatine, dimethylamine, and histidine in comparison to VOO one. In addition, FOOT decreased the plasma levels of glycine and DMSO2 compared to VOO, while FOO decreased the circulating alanine concentrations but increased the plasma levels of acetone and 3-HB compared to VOO. Based on these findings, phenol-enriched OOs were shown to result in a favorable shift in the circulating metabolic phenotype, inducing a reduction in metabolites associated with cardiometabolic diseases.
dc.description.sponsorship It was supported by the Spanish Ministry of Science and Innovation (MICINN) financing the projects AGL2009-13517-C03-01, AGL2009-13517-C03-02, AGL2009-13517-C03-03, and AGL2012-40144-C03-01. It was also supported by the Instituto de Salud Carlos III (Co-funded by the European Regional Development Fund [ERDF], a way to build Europe), financing the CIBEROBN-stay fellowship and Sara Borrell contract (CD17/00233) to M. Farràs. The PI1800164 project to F.B.-V, and the PI20/01090 project, and the Miguel Servet Program to J.M.-P. CIBERCV, CIBERDEM, and CIBEROBN are initiatives of Instituto de Salud Carlos III.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2022 by Farràs M, Swann JR, Rowland I, Rubió L, Subirana I, Catalán Ú, Motilva MJ, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/antiox11101964
dc.subject.keyword Cardiovascular diseases
dc.subject.keyword Functional olive oil
dc.subject.keyword Metabonomics
dc.subject.keyword Phenolic compounds
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-01
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-02
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-03
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2012-40144-C03-01
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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