Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial

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  • dc.contributor.author Farràs Mañé, Marta
  • dc.contributor.author Swann, Jonathan Richard
  • dc.contributor.author Rowland, Ian
  • dc.contributor.author Rubió, Laura
  • dc.contributor.author Subirana Cachinero, Isaac
  • dc.contributor.author Catalán, Úrsula
  • dc.contributor.author Motilva, Maria-José
  • dc.contributor.author Solà, Rosa
  • dc.contributor.author Covas Planells, Maria Isabel
  • dc.contributor.author Blanco-Vaca, Francisco
  • dc.contributor.author Fitó Colomer, Montserrat
  • dc.contributor.author Mayneris Perxachs, Jordi
  • dc.date.accessioned 2023-02-22T07:19:09Z
  • dc.date.available 2023-02-22T07:19:09Z
  • dc.date.issued 2022
  • dc.description.abstract Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thirty-three hypercholesterolemic individuals who ingested for 3-weeks (25 mL/day): (1) an OO enriched with its own olive oil phenolic compounds (PCs) (500 ppm; FOO); (2) an OO enriched with its own olive oil PCs (250 ppm) plus thyme PCs (250 ppm; FOOT); and (3) a VOO with low phenolic content (80 ppm). Serum lipid and glycemic profiles, serum 1H-NMR spectroscopy-based metabolomics, endothelial function, blood pressure, and cardiovascular risk were measured. We combined OPLS-DA with machine learning modelling to identify metabolites discrimination of the treatment groups. Both phenol-enriched OO interventions decreased the levels of glutamine, creatinine, creatine, dimethylamine, and histidine in comparison to VOO one. In addition, FOOT decreased the plasma levels of glycine and DMSO2 compared to VOO, while FOO decreased the circulating alanine concentrations but increased the plasma levels of acetone and 3-HB compared to VOO. Based on these findings, phenol-enriched OOs were shown to result in a favorable shift in the circulating metabolic phenotype, inducing a reduction in metabolites associated with cardiometabolic diseases.
  • dc.description.sponsorship It was supported by the Spanish Ministry of Science and Innovation (MICINN) financing the projects AGL2009-13517-C03-01, AGL2009-13517-C03-02, AGL2009-13517-C03-03, and AGL2012-40144-C03-01. It was also supported by the Instituto de Salud Carlos III (Co-funded by the European Regional Development Fund [ERDF], a way to build Europe), financing the CIBEROBN-stay fellowship and Sara Borrell contract (CD17/00233) to M. Farràs. The PI1800164 project to F.B.-V, and the PI20/01090 project, and the Miguel Servet Program to J.M.-P. CIBERCV, CIBERDEM, and CIBEROBN are initiatives of Instituto de Salud Carlos III.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Farràs M, Swann JR, Rowland I, Rubió L, Subirana I, Catalán Ú, Motilva MJ, et al. Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial. Antioxidants (Basel). 2022 Sep 30; 11(10): 1964. DOI: 10.3390/antiox11101964
  • dc.identifier.doi http://dx.doi.org/10.3390/antiox11101964
  • dc.identifier.issn 2076-3921
  • dc.identifier.uri http://hdl.handle.net/10230/55837
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-01
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-02
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-03
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2012-40144-C03-01
  • dc.rights Copyright © 2022 by Farràs M, Swann JR, Rowland I, Rubió L, Subirana I, Catalán Ú, Motilva MJ, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Cardiovascular diseases
  • dc.subject.keyword Functional olive oil
  • dc.subject.keyword Metabonomics
  • dc.subject.keyword Phenolic compounds
  • dc.title Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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