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Genetics and epigenetics of spontaneous intracerebral hemorrhage

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dc.contributor.author Giralt-Steinhauer, Eva
dc.contributor.author Jiménez-Balado, Joan
dc.contributor.author Fernández-Pérez, Isabel
dc.contributor.author Rey Álvarez, Lucía
dc.contributor.author Rodríguez-Campello, Ana
dc.contributor.author Ois Santiago, Angel Javier
dc.contributor.author Cuadrado-Godia, Elisa
dc.contributor.author Jiménez Conde, Jordi
dc.contributor.author Roquer, Jaume
dc.date.accessioned 2023-01-31T07:14:45Z
dc.date.available 2023-01-31T07:14:45Z
dc.date.issued 2022
dc.identifier.citation Giralt-Steinhauer E, Jiménez-Balado J, Fernández-Pérez I, Rey Álvarez L, Rodríguez-Campello A, Ois Á, Cuadrado-Godia E, Jiménez-Conde J, Roquer J. Genetics and epigenetics of spontaneous intracerebral hemorrhage. Int J Mol Sci. 2022 Jun 9;23(12):6479. DOI: 10.3390/ijms23126479
dc.identifier.issn 1422-0067
dc.identifier.uri http://hdl.handle.net/10230/55491
dc.description.abstract Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Int J Mol Sci. 2022 Jun 9;23(12):6479
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Genetics and epigenetics of spontaneous intracerebral hemorrhage
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijms23126479
dc.subject.keyword Epigenetics
dc.subject.keyword Genetics
dc.subject.keyword Intracerebral hemorrhage
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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