Genetics and epigenetics of spontaneous intracerebral hemorrhage

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• dc.contributor.author Giralt-Steinhauer, Eva
• dc.contributor.author Jiménez-Balado, Joan
• dc.contributor.author Fernández-Pérez, Isabel
• dc.contributor.author Rey Álvarez, Lucía
• dc.contributor.author Rodríguez-Campello, Ana
• dc.contributor.author Ois Santiago, Angel Javier
• dc.contributor.author Cuadrado-Godia, Elisa
• dc.contributor.author Jiménez Conde, Jordi
• dc.contributor.author Roquer, Jaume
• dc.date.accessioned 2023-01-31T07:14:45Z
• dc.date.available 2023-01-31T07:14:45Z
• dc.date.issued 2022
• dc.description.abstract Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
• dc.format.mimetype application/pdf
• dc.identifier.citation Giralt-Steinhauer E, Jiménez-Balado J, Fernández-Pérez I, Rey Álvarez L, Rodríguez-Campello A, Ois Á, Cuadrado-Godia E, Jiménez-Conde J, Roquer J. Genetics and epigenetics of spontaneous intracerebral hemorrhage. Int J Mol Sci. 2022 Jun 9;23(12):6479. DOI: 10.3390/ijms23126479
• dc.identifier.doi http://dx.doi.org/10.3390/ijms23126479
• dc.identifier.issn 1422-0067
• dc.identifier.uri http://hdl.handle.net/10230/55491
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Int J Mol Sci. 2022 Jun 9;23(12):6479
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Epigenetics
• dc.subject.keyword Genetics
• dc.subject.keyword Intracerebral hemorrhage
• dc.title Genetics and epigenetics of spontaneous intracerebral hemorrhage
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion