• Type 2 diabetes mellitus and cancer: epidemiology, physiopathology and prevention

  Rey-Reñones, Cristina; Baena Díez, Jose M.; Aguilar-Palacio, Isabel; Miquel, Cristina; Grau Magaña, Maria (MDPI, 2021)

  Individuals with type 2 diabetes mellitus are at greater risk of developing cancer and of dying from it. Both diseases are age-related, contributing to the impact of population aging on the long-term sustainability of ...
• The 3-year effect of the mediterranean diet intervention on inflammatory biomarkers related to cardiovascular disease

  Urpi-Sardà, Mireia; Casas, Rosa; Sacanella, Emilio; Corella, Dolores; Andrés-Lacueva, Cristina; Llorach, Rafael; Garrabou, Glòria; Cardellach, Francesc; Sala Vila, Aleix; Ros, Emilio; Ruiz-Canela, Miguel; Fitó Colomer, Montserrat; Salas-Salvadó, Jordi; Estruch, Ramón (MDPI, 2021)

  The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to ...
• Systemic profiles of microRNAs, redox balance, and inflammation in lung

  Qin, Liyun; Guitart, Maria; Curull Serrano, Víctor; Sánchez-Font, Albert; Duran, Xavier; Tang, Jun; Admetlló Papiol, Mireia; Barreiro Portela, Esther (MDPI, 2021)

  Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also ...
• NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and cancer

  Espinosa Blay, Lluís (MDPI, 2021)

  IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, ...
• Air pollution, residential greenness and metabolic dysfunction during early pregnancy in the INfancia y Medio Ambiente (INMA) Cohort

  Rammah, Amal; Whitworth, Kristina W.; Amos, Christopher I.; Estarlich, Marisa; Guxens Junyent, Mònica; Ibarluzea, Jesús; Iñiguez, Carmen; Subiza-Pérez, Mikel; Vrijheid, Martine; Symanski, Elaine (MDPI, 2021)

  Despite extensive study, the role of air pollution in gestational diabetes remains unclear, and there is limited evidence of the beneficial impact of residential greenness on metabolic dysfunction during pregnancy. We used ...
• A transdisciplinary approach to recovering natural and cultural landscape and place identification: A case study of Can Moritz spring (Rubí, Spain)

  Cervera, Marina; Bell, Simon; Muñoz, Francesc; Mishra, Himansu S.; Fleming, Lora E.; Grellier, James; Carrasco Turigas, Glòria; Nieuwenhuijsen, Mark J.; Vert Roca, Cristina, 1991-; Gascon Merlos, Mireia, 1984- (MDPI, 2021)

  The perception of the quality of green and blue spaces can be key in the relationship between a community and its local landscape (i.e., place identification). The lack of transdisciplinary training and social-specific ...
• Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits

  Ruiz Arenas, Carlos, 1990-; Cáceres, Alejandro; López, Marcos; Pelegrí-Sisó, Dolors; González, Josefa; González, Juan Ramón (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)

  Recombination is a main source of genetic variability. However, the potential role of the variation generated by recombination in phenotypic traits, including diseases, remains unexplored because there is currently no ...
• The EU Child Cohort Network's core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

  Pinot de Moira, Angela; Fernández-Barrés, Sílvia; Vrijheid, Martine; LifeCycle Project Group (Springer, 2021)

  The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on ...
• Heart healthy cities: genetics loads the gun but the environment pulls the trigger

  Münzel, Thomas; Sørensen, Mette; Lelieveld, Jos; Hahad, Omar; Al-Kindi, Sadeer; Nieuwenhuijsen, Mark J.; Giles-Corti, Billie; Daiber, Andreas; Rajagopalan, Sanjay T. (Oxford University Press, 2021)

  The world's population is estimated to reach 10 billion by 2050 and 75% of this population will live in cities. Two-third of the European population already live in urban areas and this proportion continues to grow. Between ...
• Associations between road traffic noise exposure at home and school and ADHD in school-aged children: the TRAILS study

  Zijlema, Wilma; de Kluizenaar, Y.; van Kamp, Irene; Hartman, Catharina A. (Springer, 2021)

  Environmental noise may play a role in the manifestation and severity of attention deficit/hyperactivity disorder (ADHD) symptoms, but evidence is limited. We investigated the cross-sectional associations between residential ...
• Genomic footprints of activated telomere maintenance mechanisms in cancer

  Sieverling, Lina; Hong, Chen; Koser, Sandra D.; Ginsbach, Philip; Kleinheinz, Kortine; Hutter, Barbara; Braun, Delia M.; Cortés-Ciriano, Isidro; Xi, Ruibin; Kabbe, Rolf; Park, Peter J.; Eils, Roland; Schlesner, Matthias; PCAWG Structural Variation Working Group; Brors, Benedikt; Rippe, Karsten; Jones, David T. W.; Feuerbach, Lars; PCAWG Consortium; Ossowski, Stephan; Estivill, Xavier, 1955- (Nature Research, 2020)

  Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ...
• Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

  Helmsauer, Konstantin; Rodriguez-Fos, Elias; Puiggròs, Montserrat; Torrents, David; Koche, Richard P. (Nature Research, 2020)

  MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA). The exact amplicon structure has not been described ...
• E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

  Dahlet, Thomas; Truss, Matthias; Frede, Ute; Al Adhami, Hala; Bardet, Anaïs F.; Dumas, Michael; Vallet, Judith; Chicher, Johana; Hammann, Philippe; Kottnik, Sarah; Hansen, Peter; Luz, Uschi; Alvarez, Gonzalo; Auclair, Ghislain; Hecht, Jochen; Robinson, Peter N.; Hagemeier, Christian; Weber, Michael (Nature Research, 2021)

  In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the ...
• A RAC-GEF network critical for early intestinal tumourigenesis

  Pickering, Karen; Unal, E. Besray; Kiel, Christina; Serrano Pubull, Luis, 1982-; Sansom, Owen J. (Nature Research, 2021)

  RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, ...
• Federated discovery and sharing of genomic data using Beacons

  Fiume, Marc; Rambla de Argila, Jordi; Torre, Sabela de la; Scollen, Serena (Nature Research, 2019)
• Stuck in a time warp? The Great Recession and the socio-occupational integration of migrants in Spain

  Jiménez-García, Juan Ramón; Levatino, Antonia (Springer, 2022)

  This article examines the socio-occupational integration of the immigrant population in Spain for a time span that, for the first time, includes the post-crisis period. Using the Spanish Labour Force Survey and conducting ...
• A multi-scale approach to interculturalism: from globalised politics to localised policy and practice

  Zapata Barrero, Ricard; Mansouri, Fethi (Springer, 2022)

  Interculturalism (IC) is presently discussed as a foundational basis for local public policy aimed at managing migration-related diversity within ethno-culturally plural societies, especially at the local level. Despite ...
• Modern colonialism and cultural continuity through material culture: an example from Guam and CHamoru plaiting

  Montón Subías, Sandra; Hernando Gonzalo, Almudena (Springer, 2021)

  This article analyzes cultural persistence in Guam through plaiting, material culture, and maintenance activities, a set of daily practices that are essential to social continuity and well-being. The colonization of Guam ...
• Business cycle and mortality in Spain

  Cervini, María; Vall Castelló, Judit (Springer, 2021)

  In the last couple of decades, there has been a lot of interest on the impact of macroeconomic fluctuations on health and mortality rates. Many studies, for different countries, find that mortality is procyclical. However, ...
• What’s really wrong with fining crimes? On the hard treatment of criminal monetary fines

  Coca Vila, Ivó (Springer, 2021)

  Among the advocates of expressive theories of punishment, there is a strong consensus that monetary fines cannot convey the message of censure that is required to punish serious crimes or crimes against the person (e.g., ...

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