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  • Goodstadt, Mike N.; Martí Renom, Marc A. (Elsevier, 2019)
    Genome discoveries at the core of biology are made by visual description and exploration of the cell, from microscopic sketches and biochemical mapping to computational analysis and spatial modeling. We outline the ...
  • Rosas Salvans, Miquel, 1987-; Scrofani, Jacopo, 1984-; Modol, Aitor; Vernos, Isabelle, 1959- (Company of Biologists, 2019)
    Bipolar spindle organization is essential for the faithful segregation of chromosomes during cell division. This organization relies on the collective activities of motor proteins. The minus-end-directed dynein motor complex ...
  • Ogando, Jesús; Sáez, María Eugenia; Santos, Javier; Nuevo-Tapioles, Cristina; Gut, Marta; Esteve-Codina, Anna; Heath, Simon; González-Pérez, Antonio; Cuezva, José M.; Lacalle, Rosa Ana; Mañes, Santos (BioMed Central, 2019)
    Background: Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer ...
  • Roman-Canal, Berta; Tarragona, Jordi; Moiola, Cristian Pablo; Gatius, Sònia; Bonnin, Sarah; Ruiz-Miró, Maria; Sierra, José Enrique; Rufas, Maria; González, Esperanza; Porcel, José M.; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colas, Eva (BioMed Central, 2019)
    Background: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, ...
  • Iacono, Giovanni; Massoni-Badosa, Ramon; Heyn, Holger (BioMed Central, 2019)
    Background: Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our understanding of cellular heterogeneity. Current analytical workflows are driven by categorizing principles that consider cells as individual ...
  • Hitte, Christophe; Le Béguec, Céline; Cadieu, Edouard; Wucher, Valentin; Primot, Aline; Prouteau, Anaïs; Botherel, Nadine; Hédan, Benoit; Lindblad-Toh, Kerstin; André, Catherine; Derrien, Thomas (MDPI, 2019)
    Mucosal melanomas (MM) are rare aggressive cancers in humans, and one of the most common forms of oral cancers in dogs. Similar biological and histological features are shared between MM in both species, making dogs a ...
  • Mallol, Anna; Guirola, Maria; Payer, Bernhard, 1975- (BioMed Central, 2019)
    Background: In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a ...
  • Cuadrado, Ana; Giménez-Llorente, Daniel; Kojic, Aleksandar; Rodríguez-Corsino, Miriam; Cuartero, Yasmina; Martín-Serrano, Guillermo; Gómez López, Gonzalo; Marti-Renom, Marc A.; Losada, Ana (Elsevier, 2019)
    Cohesin exists in two variants carrying either STAG/SA1 or SA2. Here we have addressed their specific contributions to the unique spatial organization of the mouse embryonic stem cell genome, which ensures super-enhancer-dependent ...
  • Roman-Canal, Berta; Pablo-Moiola, Cristian; Gatius, Sònia; Bonnin, Sarah; Ruiz-Miró, Maria; González, Esperanza; González-Tallada, Xavier; Llordella, Ivanna; Hernández, Isabel; Porcel, José M.; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colas, Eva (MDPI, 2019)
    Endometrial cancer (EC) is the sixth most common cancer in women worldwide and is responsible for more than 89,000 deaths every year. Mortality is associated with presence of poor prognostic factors at diagnosis, i.e., ...
  • Porcaro, Lorenzo; Gómez Gutiérrez, Emilia, 1975- (2019)
    Listening to music radios is an activity that since the 20th century is part of the cultural habits for people all over the world. While in the case of analog radios DJs are in charge of selecting the music to be ...
  • Pegueroles Queralt, Maria Cinta; Iraola Guzman, Susana; Chorostecki, Uciel; Ksiezopolska, Ewa; Saus Martínez, Ester; Gabaldón Estevan, Juan Antonio, 1973- (Taylor & Francis, 2019)
    Long non-coding RNAs (lncRNAs) are a heterogeneous class of genes that do not code for proteins. Since lncRNAs (or a fraction thereof) are expected to be functional, many efforts have been dedicated to catalog lncRNAs in ...
  • Raote, Ishier; Malhotra, Vivek (Rockefeller University Press, 2019)
    Palade's corpus placed small vesicles as the sole means to transport proteins across stable distinct compartments of the secretory pathway. We suggest that cargo, spatial organization of secretory compartments, and the ...
  • Thompson, Rachel; Bonne, Gisèle; Missier, Paolo; Lochmüller, Hanns (Portland Press, 2019)
    Despite recent scientific advances, most rare genetic diseases - including most neuro-muscular diseases - do not currently have curative gene-based therapies available. However, in some cases, such as vitamin, cofactor or ...
  • Germann, Philipp; Marin-Riera, Miquel; Sharpe, James (Elsevier, 2019)
    Simulating morphogenesis of both mesenchyme and epithelium has typically required complex and computationally expensive models. To meet this challenge, we developed ya||a-yet another parallel agent-based model. Our model ...
  • Voltes Cobo, Adrià, 1991-; Hevia, Covadonga F.; Engel-Pizcueta, Carolyn; Dingare, Chaitanya; Calzolari, Simone, 1983-; Terriente, Javier; Norden, Caren; Lecaudey, Virginie; Pujades Corbi, Cristina (Company of Biologists, 2019)
    Cells perceive their microenvironment through chemical and physical cues. However, how the mechanical signals are interpreted during embryonic tissue deformation to result in specific cell behaviors is largely unknown. The ...
  • Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Daza, Vanesa; Herranz, Javier; Morillo, Paz; Ràfols, Carla (Springer, 2007)
    In a threshold broadcast encryption scheme, a sender chooses (ad-hoc) a set of n receivers and a threshold t, and then encrypts a message by using the public keys of all the receivers, in such a way that the original ...
  • Daza, Vanesa; Morillo, Paz; Ràfols, Carla (Elsevier, 2007)
    Identity-Based cryptography has been proposed in mobile ad-hoc networks (MANETs) to provide security. However, the figure of the Private Key Generator (PKG) is not adequate in the MANET setting, since it may not be ...
  • Daza, Vanesa; Herranz, Javier; Morillo, Paz; Ràfols, Carla (Elsevier, 2008)
    In a threshold broadcast encryption scheme, a sender chooses (ad-hoc) a set of n receivers and a threshold t, and then encrypts a message by using the public keys of all the receivers, in such a way that the original plaintext ...
  • Morillo, Paz; Ràfols, Carla (Springer, 2009)
    The relation between list decoding and hard-core predicates has provided a clean and easy methodology to prove the hardness of certain predicates. So far this methodology has only been used to prove that the O(log logN) ...

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