dc.contributor.author |
López-Botet, Miguel |
dc.contributor.author |
Maria, Andrea de |
dc.contributor.author |
Muntasell i Castellví, Aura, 1972- |
dc.contributor.author |
Della Chiesa, Mariella |
dc.contributor.author |
Vilches, Carlos |
dc.date.accessioned |
2023-01-17T12:57:47Z |
dc.date.available |
2023-01-17T12:57:47Z |
dc.date.issued |
2023 |
dc.identifier.citation |
López-Botet M, De Maria A, Muntasell A, Della Chiesa M, Vilches C. Adaptive NK cell response to human cytomegalovirus: Facts and open issues. Semin Immunol. 2023 Jan;65:101706. DOI: 10.1016/j.smim.2022.101706 |
dc.identifier.issn |
1044-5323 |
dc.identifier.uri |
http://hdl.handle.net/10230/55316 |
dc.description.abstract |
Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system. These include the differentiation and persistent expansion of a mature NK cell subset which displays a characteristic phenotypic and functional profile hallmarked by expression of the HLA-E-specific CD94/NKG2C activating receptor. Based on our experience and recent advances in the field, we overview the adaptive features of the NKG2C+ NK cell response, discussing observations and open questions on: (a) the mechanisms and influence of viral and host factors; (b) the existence of other NKG2C- NK cell subsets sharing adaptive features; (c) the development and role of adaptive NKG2C+ NK cells in the response to HCMV in hematopoietic and solid organ transplant patients; (d) their relation with other viral infections, mainly HIV-1; and (e) current perspectives for their use in adoptive immunotherapy of cancer. |
dc.description.sponsorship |
Research is supported by: Agencia Estatal de Investigación-FEDER (PID2019–110609RB-C21-C22/AEI/10.13039/501100011033); Fundació La Marató de TV3 (201822–10); Ministero dell’Istruzione (MIUR) - FRA 219; Ministero dell’Istruzione (MIUR): FISR2020IP_02937; ISCiii/FEDER (PI19/00328; PI22/00040) and CIBERONC. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Elsevier |
dc.relation.ispartof |
Semin Immunol. 2023 Jan;65:101706 |
dc.rights |
© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
dc.title |
Adaptive NK cell response to human cytomegalovirus: Facts and open issues |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.1016/j.smim.2022.101706 |
dc.subject.keyword |
Cancer |
dc.subject.keyword |
Cytomegalovirus |
dc.subject.keyword |
Infection |
dc.subject.keyword |
NK cells |
dc.subject.keyword |
NKG2C |
dc.subject.keyword |
Transplantation |
dc.relation.projectID |
info:eu-repo/grantAgreement/ES/2PE/PID2019–110609RB-C21 |
dc.relation.projectID |
info:eu-repo/grantAgreement/ES/2PE/PID2019–110609RB-C22 |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/publishedVersion |