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One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study

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dc.contributor.author Marhuenda Muñoz, María
dc.contributor.author Domínguez-López, Inés
dc.contributor.author Laveriano-Santos, Emily P.
dc.contributor.author Parilli-Moser, Isabella
dc.contributor.author Razquin, Cristina
dc.contributor.author Ruiz-Canela, Miguel
dc.contributor.author Basterra-Gortari, F. Javier
dc.contributor.author Salas-Salvadó, Jordi
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Lapetra, José
dc.contributor.author Arós, Fernando
dc.contributor.author Fiol, Miquel
dc.contributor.author Serra-Majem, Luis
dc.contributor.author Pintó Sala, Xavier
dc.contributor.author Gómez-Gracia, Enrique
dc.contributor.author Ros, Emilio
dc.contributor.author Estruch, Ramón
dc.contributor.author Lamuela-Raventós, Rosa M.
dc.date.accessioned 2023-01-16T07:31:01Z
dc.date.available 2023-01-16T07:31:01Z
dc.date.issued 2022
dc.identifier.citation Marhuenda-Muñoz M, Domínguez-López I, Laveriano-Santos EP, Parilli-Moser I, Razquin C, Ruiz-Canela M, et al. One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study. Antioxidants (Basel). 2022 Aug 8; 11(8): 1540. DOI: 10.3390/antiox11081540
dc.identifier.issn 2076-3921
dc.identifier.uri http://hdl.handle.net/10230/55274
dc.description.abstract The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
dc.description.sponsorship This research was funded by CICYT [AGL2016-75329-R] PID2020-114022RB-I00, CIBEROBN Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER 10.13039/501100011033, UE), and Generalitat de Catalunya (GC) [2017SGR196]. M.M.-M. is supported by the FPU17/00513 grant. I.D.-L. thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU20/02478) contract. E.P.L.-S. is supported by the FI-SDUR (EM/3345/2020) grant from the Generalitat de Catalunya. I.P.-M. is supported by the FI-SDUR (EMC/2703/2019).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights © Marhuenda-Muñoz M, Domínguez-López I, Laveriano-Santos EP, Parilli-Moser I, Razquin C, Ruiz-Canela M, et al.. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/antiox11081540
dc.subject.keyword Mediterranean diet
dc.subject.keyword PREDIMED study
dc.subject.keyword Bioactive compounds
dc.subject.keyword Cardiovascular
dc.subject.keyword Liquid chromatography
dc.subject.keyword Mass spectrometry
dc.subject.keyword Phytochemicals
dc.subject.keyword Urinary microbial phenolic metabolites
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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