One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study

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• dc.contributor.author Marhuenda Muñoz, María
• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Laveriano-Santos, Emily P.
• dc.contributor.author Parilli-Moser, Isabella
• dc.contributor.author Razquin, Cristina
• dc.contributor.author Ruiz-Canela, Miguel
• dc.contributor.author Basterra-Gortari, F. Javier
• dc.contributor.author Salas-Salvadó, Jordi
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Lapetra, José
• dc.contributor.author Arós, Fernando
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Serra-Majem, Luis
• dc.contributor.author Pintó Sala, Xavier
• dc.contributor.author Gómez-Gracia, Enrique
• dc.contributor.author Ros, Emilio
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Lamuela-Raventós, Rosa M.
• dc.date.accessioned 2023-01-16T07:31:01Z
• dc.date.available 2023-01-16T07:31:01Z
• dc.date.issued 2022
• dc.description.abstract The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
• dc.description.sponsorship This research was funded by CICYT [AGL2016-75329-R] PID2020-114022RB-I00, CIBEROBN Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER 10.13039/501100011033, UE), and Generalitat de Catalunya (GC) [2017SGR196]. M.M.-M. is supported by the FPU17/00513 grant. I.D.-L. thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU20/02478) contract. E.P.L.-S. is supported by the FI-SDUR (EM/3345/2020) grant from the Generalitat de Catalunya. I.P.-M. is supported by the FI-SDUR (EMC/2703/2019).
• dc.format.mimetype application/pdf
• dc.identifier.citation Marhuenda-Muñoz M, Domínguez-López I, Laveriano-Santos EP, Parilli-Moser I, Razquin C, Ruiz-Canela M, et al. One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study. Antioxidants (Basel). 2022 Aug 8; 11(8): 1540. DOI: 10.3390/antiox11081540
• dc.identifier.doi http://dx.doi.org/10.3390/antiox11081540
• dc.identifier.issn 2076-3921
• dc.identifier.uri http://hdl.handle.net/10230/55274
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
• dc.rights © Marhuenda-Muñoz M, Domínguez-López I, Laveriano-Santos EP, Parilli-Moser I, Razquin C, Ruiz-Canela M, et al.. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword PREDIMED study
• dc.subject.keyword Bioactive compounds
• dc.subject.keyword Cardiovascular
• dc.subject.keyword Liquid chromatography
• dc.subject.keyword Mass spectrometry
• dc.subject.keyword Phytochemicals
• dc.subject.keyword Urinary microbial phenolic metabolites
• dc.title One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion