dc.contributor.author |
Soldado-Folgado, Jade |
dc.contributor.author |
Chillarón Jordan, Juan José |
dc.contributor.author |
Cañas-Ruano, Esperanza |
dc.contributor.author |
Arrieta Aldea, Itziar |
dc.contributor.author |
González Mena, Alicia |
dc.contributor.author |
Blasco-Hernando, Fabiola |
dc.contributor.author |
Knobel Freud, Hernando |
dc.contributor.author |
García-Giralt, Natalia |
dc.contributor.author |
Güerri Fernández, Roberto |
dc.date.accessioned |
2022-11-14T07:57:42Z |
dc.date.available |
2022-11-14T07:57:42Z |
dc.date.issued |
2022 |
dc.identifier.citation |
Soldado-Folgado J, Chillarón JJ, Cañas-Ruano E, Arrieta-Aldea I, González-Mena A, Blasco-Hernando F, et al. An abnormal inflammatory pattern associated with long-term non-progression of HIV infection impacts negatively on bone quality. J Clin Med. 2022 May 22; 11(10): 2927. DOI: 10.3390/jcm11102927 |
dc.identifier.issn |
2077-0383 |
dc.identifier.uri |
http://hdl.handle.net/10230/54835 |
dc.description.abstract |
Long-term non-progressors (LTNPs) are HIV-infected individuals (HIV+) whose viral replication is controlled. However, these individuals experience complications associated with HIV, among them, bone remodeling impairment. This study aims to perform a comprehensive bone health assessment and its association with the inflammatory status of HIV+ LTNPs. A cross-sectional study was conducted comparing bone strength components (bone mineral density and bone tissue quality) between age-, sex-, and comorbidities-matched groups of HIV+ LTNPs, HIV+ progressors, and HIV-negative individuals. A panel of bone turnover and inflammatory biomarkers was measured in fasting plasma using ELISA. Bone tissue quality was assessed by bone microindentation, a technique that directly measures the bone resistance to fracture and yields a dimensionless quantifiable parameter called bone material strength (BMSi). Thirty patients were included: ten LTNPs, ten HIV+ progressors, and ten HIV-negative individuals. LTNPs showed an abnormal pattern of immune activation that was represented by significantly lower levels of anti-inflammatory cytokine IL-10 (p = 0.03), pro-inflammatory cytokine IL-8 (p = 0.01), and TNF-α (p < 0.001) with respect to the other groups. Regarding bone health, LTNPs presented lower BMSi, and thus, worse bone tissue quality than HIV-negative individuals (83 (78-85) vs. 90 (89-93), respectively; p = 0.003), and also lower BMSi than HIV+ progressors (83 (78-85) vs. 86 (85-89), respectively; p = 0.022). A trend was found of lower BMSi in HIV+ progressors with respect to the HIV-negative individuals (86 (85-89) vs. 90 (89-93), respectively; p = 0.083). No differences were detected in bone mineral density between groups. In conclusion, LTNPs showed a different inflammatory profile, along with worse bone tissue quality, when compared to HIV+ progressors and HIV-negative individuals. This may contribute to increasing evidence that HIV infection itself has a deleterious effect on bone tissue, likely through a persistent altered inflammation status. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
MDPI |
dc.rights |
Copyright © 2022. Soldado-Folgado J, Chillarón JJ, Cañas-Ruano E, Arrieta-Aldea I, González-Mena A, Blasco-Hernando F, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
dc.title |
An abnormal inflammatory pattern associated with long-term non-progression of HIV infection impacts negatively on bone quality |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.3390/jcm11102927 |
dc.subject.keyword |
HIV |
dc.subject.keyword |
Bone metabolism |
dc.subject.keyword |
Cytokines |
dc.subject.keyword |
Immunoactivation |
dc.subject.keyword |
Inflammation |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/publishedVersion |