An abnormal inflammatory pattern associated with long-term non-progression of HIV infection impacts negatively on bone quality
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- dc.contributor.author Soldado Folgado, Jade
- dc.contributor.author Chillarón Jordan, Juan José
- dc.contributor.author Cañas-Ruano, Esperanza
- dc.contributor.author Arrieta Aldea, Itziar
- dc.contributor.author González Mena, Alicia
- dc.contributor.author Blasco-Hernando, Fabiola
- dc.contributor.author Knobel Freud, Hernando
- dc.contributor.author García-Giralt, Natalia
- dc.contributor.author Güerri Fernández, Roberto
- dc.date.accessioned 2022-11-14T07:57:42Z
- dc.date.available 2022-11-14T07:57:42Z
- dc.date.issued 2022
- dc.description.abstract Long-term non-progressors (LTNPs) are HIV-infected individuals (HIV+) whose viral replication is controlled. However, these individuals experience complications associated with HIV, among them, bone remodeling impairment. This study aims to perform a comprehensive bone health assessment and its association with the inflammatory status of HIV+ LTNPs. A cross-sectional study was conducted comparing bone strength components (bone mineral density and bone tissue quality) between age-, sex-, and comorbidities-matched groups of HIV+ LTNPs, HIV+ progressors, and HIV-negative individuals. A panel of bone turnover and inflammatory biomarkers was measured in fasting plasma using ELISA. Bone tissue quality was assessed by bone microindentation, a technique that directly measures the bone resistance to fracture and yields a dimensionless quantifiable parameter called bone material strength (BMSi). Thirty patients were included: ten LTNPs, ten HIV+ progressors, and ten HIV-negative individuals. LTNPs showed an abnormal pattern of immune activation that was represented by significantly lower levels of anti-inflammatory cytokine IL-10 (p = 0.03), pro-inflammatory cytokine IL-8 (p = 0.01), and TNF-α (p < 0.001) with respect to the other groups. Regarding bone health, LTNPs presented lower BMSi, and thus, worse bone tissue quality than HIV-negative individuals (83 (78-85) vs. 90 (89-93), respectively; p = 0.003), and also lower BMSi than HIV+ progressors (83 (78-85) vs. 86 (85-89), respectively; p = 0.022). A trend was found of lower BMSi in HIV+ progressors with respect to the HIV-negative individuals (86 (85-89) vs. 90 (89-93), respectively; p = 0.083). No differences were detected in bone mineral density between groups. In conclusion, LTNPs showed a different inflammatory profile, along with worse bone tissue quality, when compared to HIV+ progressors and HIV-negative individuals. This may contribute to increasing evidence that HIV infection itself has a deleterious effect on bone tissue, likely through a persistent altered inflammation status.
- dc.format.mimetype application/pdf
- dc.identifier.citation Soldado-Folgado J, Chillarón JJ, Cañas-Ruano E, Arrieta-Aldea I, González-Mena A, Blasco-Hernando F, et al. An abnormal inflammatory pattern associated with long-term non-progression of HIV infection impacts negatively on bone quality. J Clin Med. 2022 May 22; 11(10): 2927. DOI: 10.3390/jcm11102927
- dc.identifier.doi http://dx.doi.org/10.3390/jcm11102927
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/54835
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2022. Soldado-Folgado J, Chillarón JJ, Cañas-Ruano E, Arrieta-Aldea I, González-Mena A, Blasco-Hernando F, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword HIV
- dc.subject.keyword Bone metabolism
- dc.subject.keyword Cytokines
- dc.subject.keyword Immunoactivation
- dc.subject.keyword Inflammation
- dc.title An abnormal inflammatory pattern associated with long-term non-progression of HIV infection impacts negatively on bone quality
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion