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Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption

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dc.contributor.author López Montesinos, Inmaculada
dc.contributor.author Arrieta Aldea, Itziar
dc.contributor.author Dicastillo, Aitor
dc.contributor.author Zuccarino, Flavio
dc.contributor.author Sorli Redó, M. Luisa
dc.contributor.author Güerri Fernández, Roberto
dc.contributor.author Arnau-Barrés, Isabel
dc.contributor.author Milagro Montero, Maria
dc.contributor.author Siverio-Parès, Ana
dc.contributor.author Duran Jordà, Xavier, 1974-
dc.contributor.author Arenas-Miras, María Del Mar
dc.contributor.author Brasé Arnau, Ariadna
dc.contributor.author Cañas-Ruano, Esperanza
dc.contributor.author Castañeda, Silvia
dc.contributor.author Kamber, Ignacio Domingo
dc.contributor.author Gómez Junyent, Joan
dc.contributor.author Pelegrín, Iván
dc.contributor.author Sánchez Martínez, Francisca
dc.contributor.author Sendra, Elena
dc.contributor.author Suaya Leiro, Lucía
dc.contributor.author Villar García, Judit
dc.contributor.author Nogués Solan, Francesc Xavier
dc.contributor.author Grau Cerrato, Santiago
dc.contributor.author Knobel Freud, Hernando
dc.contributor.author Gómez-Zorrilla, Silvia
dc.contributor.author Horcajada Gallego, Juan Pablo
dc.contributor.author COVID-MAR Group
dc.date.accessioned 2022-10-17T06:25:57Z
dc.date.issued 2022
dc.identifier.citation López Montesinos I, Arrieta-Aldea I, Dicastillo A, Zuccarino F, Sorli L, Guerri-Fernández R et al. Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption. Clin Infect Dis. 2022 Dec 19;75(12):2225-38. DOI: 10.1093/cid/ciac314
dc.identifier.issn 1058-4838
dc.identifier.uri http://hdl.handle.net/10230/54421
dc.description.abstract Background: To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. Methods: Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted due to seasonal influenza between 2017 and 2019, or with COVID-19 between March and May 2020 requiring supplemental oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality and hospitalization costs. Attempted sample size to detect an 11% difference in mortality was 187 patients per group. Results: COVID-19 cases were younger (median years, 67 (IQR 54-78) vs 76 (IQR 64-83); p < 0.001) and more frequently overweight whereas influenza cases had more hypertension, immunosuppression, and chronic heart, respiratory and renal disease. Compared to influenza, COVID-19 cases had more pneumonia (98% vs 60%, <0.001), higher MEWS and CURB-65 scores and were more likely to show worse progression on the WHO ordinal scale (33% vs 4%; p < 0.001). The 30-day mortality rate was higher for COVID-19 than for influenza: 15% vs 5% (p = 0.001). The median age of non-surviving cases was 81 (IQR 74-88) and 77.5 (IQR 65-84) (p = 0.385), respectively. COVID-19 was independently associated with 30-day (HR 4.6, 95%CI, 2-10.4) and 90-day (HR 5.2, 95%CI, 2.4-11.4) mortality. Sensitivity and subgroup analyses, including a subgroup considering only patients with pneumonia, did not show different trends. Regarding resource consumption, COVID-19 patients had longer hospital stays and higher critical care, pharmacy, and complementary test costs. Conclusions: Although influenza patients were older and had more comorbidities, COVID-19 cases requiring supplemental oxygen on admission had worse clinical and economic outcomes.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Clin Infect Dis. 2022 Dec 19;75(12):2225-38
dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical infectious diseases: an official publication of the Infectious Diseases Society of America following peer review. The version of record López Montesinos I, Arrieta-Aldea I, Dicastillo A, Zuccarino F, Sorli L, Guerri-Fernández R et al. Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption. Clin Infect Dis. 2022 Apr 20:ciac314. DOI: 10.1093/cid/ciac314 is available online at: http://dx.doi.org/10.1093/cid/ciac314
dc.title Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/cid/ciac314
dc.subject.keyword COVID-19
dc.subject.keyword Flu
dc.subject.keyword Hospital costs
dc.subject.keyword Mortality
dc.subject.keyword Pandemic
dc.subject.keyword Resource consumption
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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