Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption

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• dc.contributor.author López Montesinos, Inmaculada
• dc.contributor.author Arrieta Aldea, Itziar
• dc.contributor.author Dicastillo, Aitor
• dc.contributor.author Zuccarino, Flavio
• dc.contributor.author Sorli Redó, M. Luisa
• dc.contributor.author Güerri Fernández, Roberto
• dc.contributor.author Arnau-Barrés, Isabel
• dc.contributor.author Milagro Montero, Maria
• dc.contributor.author Siverio-Parès, Ana
• dc.contributor.author Duran Jordà, Xavier, 1974-
• dc.contributor.author Arenas-Miras, María Del Mar
• dc.contributor.author Brasé Arnau, Ariadna
• dc.contributor.author Cañas-Ruano, Esperanza
• dc.contributor.author Castañeda, Silvia
• dc.contributor.author Kamber, Ignacio Domingo
• dc.contributor.author Gómez Junyent, Joan
• dc.contributor.author Pelegrín, Iván
• dc.contributor.author Sánchez Martínez, Francisca
• dc.contributor.author Sendra, Elena
• dc.contributor.author Suaya Leiro, Lucía
• dc.contributor.author Villar García, Judit
• dc.contributor.author Nogués Solan, Francesc Xavier
• dc.contributor.author Grau Cerrato, Santiago
• dc.contributor.author Knobel Freud, Hernando
• dc.contributor.author Gómez-Zorrilla, Silvia
• dc.contributor.author Horcajada Gallego, Juan Pablo
• dc.contributor.author COVID-MAR Group
• dc.date.accessioned 2022-10-17T06:25:57Z
• dc.date.issued 2022
• dc.description.abstract Background: To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. Methods: Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted due to seasonal influenza between 2017 and 2019, or with COVID-19 between March and May 2020 requiring supplemental oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality and hospitalization costs. Attempted sample size to detect an 11% difference in mortality was 187 patients per group. Results: COVID-19 cases were younger (median years, 67 (IQR 54-78) vs 76 (IQR 64-83); p < 0.001) and more frequently overweight whereas influenza cases had more hypertension, immunosuppression, and chronic heart, respiratory and renal disease. Compared to influenza, COVID-19 cases had more pneumonia (98% vs 60%, <0.001), higher MEWS and CURB-65 scores and were more likely to show worse progression on the WHO ordinal scale (33% vs 4%; p < 0.001). The 30-day mortality rate was higher for COVID-19 than for influenza: 15% vs 5% (p = 0.001). The median age of non-surviving cases was 81 (IQR 74-88) and 77.5 (IQR 65-84) (p = 0.385), respectively. COVID-19 was independently associated with 30-day (HR 4.6, 95%CI, 2-10.4) and 90-day (HR 5.2, 95%CI, 2.4-11.4) mortality. Sensitivity and subgroup analyses, including a subgroup considering only patients with pneumonia, did not show different trends. Regarding resource consumption, COVID-19 patients had longer hospital stays and higher critical care, pharmacy, and complementary test costs. Conclusions: Although influenza patients were older and had more comorbidities, COVID-19 cases requiring supplemental oxygen on admission had worse clinical and economic outcomes.
• dc.format.mimetype application/pdf
• dc.identifier.citation López Montesinos I, Arrieta-Aldea I, Dicastillo A, Zuccarino F, Sorli L, Guerri-Fernández R, et al. Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption. Clin Infect Dis. 2022 Dec 19;75(12):2225-38. DOI: 10.1093/cid/ciac314
• dc.identifier.doi http://dx.doi.org/10.1093/cid/ciac314
• dc.identifier.issn 1058-4838
• dc.identifier.uri http://hdl.handle.net/10230/54421
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Clin Infect Dis. 2022 Dec 19;75(12):2225-38
• dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical infectious diseases: an official publication of the Infectious Diseases Society of America following peer review. The version of record López Montesinos I, Arrieta-Aldea I, Dicastillo A, Zuccarino F, Sorli L, Guerri-Fernández R et al. Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption. Clin Infect Dis. 2022 Apr 20:ciac314. DOI: 10.1093/cid/ciac314 is available online at: http://dx.doi.org/10.1093/cid/ciac314
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword COVID-19
• dc.subject.keyword Flu
• dc.subject.keyword Hospital costs
• dc.subject.keyword Mortality
• dc.subject.keyword Pandemic
• dc.subject.keyword Resource consumption
• dc.title Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion