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Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum

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dc.contributor.author Calvo González, Xavier
dc.contributor.author Roman-Bravo, David
dc.contributor.author García Gisbert, Nieves, 1994-
dc.contributor.author Rodriguez-Sevilla, Juan José
dc.contributor.author García-Avila, Sara
dc.contributor.author Florensa Brichs, Lourdes
dc.contributor.author Gibert Fernandez, Joan 1988-
dc.contributor.author Fernández Rodríguez, M. Concepción
dc.contributor.author Salido Galeote, Marta
dc.contributor.author Puiggros Metje, Anna Maria
dc.contributor.author Espinet Solà, Blanca
dc.contributor.author Colomo Saperas, Luis Alberto
dc.contributor.author Bellosillo Paricio, Beatriz
dc.contributor.author Ferrer, Ana
dc.contributor.author Arenillas Rocha, Leonor
dc.date.accessioned 2022-10-07T06:28:17Z
dc.date.available 2022-10-07T06:28:17Z
dc.date.issued 2022
dc.identifier.citation Calvo X, Roman-Bravo D, Garcia-Gisbert N, Rodriguez-Sevilla JJ, Garcia-Avila S, Florensa L, et al. Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum. Blood Adv. 2022 Jul 12; 6(13): 3921-31. DOI: 10.1182/bloodadvances.2022007359
dc.identifier.issn 2473-9529
dc.identifier.uri http://hdl.handle.net/10230/54311
dc.description.abstract atients with oligomonocytic chronic myelomonocytic leukemia (OM-CMML) are currently classified according to the 2017 World Health Organization myelodysplastic syndromes classification. However, recent data support considering OM-CMML as a specific subtype of chronic myelomonocytic leukemia (CMML), given their similar clinical, genomic, and immunophenotypic profiles. The main purpose of our study was to provide survival outcome data of a well-annotated series of 42 patients with OM-CMML and to compare them to 162 patients with CMML, 120 with dysplastic type (D-CMML), and 42 with proliferative type (P-CMML). OM-CMML had significantly longer overall survival (OS) and acute myeloid leukemia-free survival than did patients with CMML, considered as a whole group, and when compared with D-CMML and P-CMML. Moreover, gene mutations associated with increased proliferation (ie, ASXL1 and RAS-pathway mutations) were identified as independent adverse prognostic factors for OS in our series. We found that at a median follow-up of 53.47 months, 29.3% of our patients with OM-CMML progressed to D-CMML, and at a median follow-up of 46.03 months, 28.6% of our D-CMML group progressed to P-CMML. These data support the existence of an evolutionary continuum of OM-CMML, D-CMML, and P-CMML. In this context, we observed that harboring more than 3 mutated genes, carrying ASXL1 mutations, and a peripheral blood monocyte percentage >20% significantly predicted a shorter time of progression of OM-CMML into overt CMML. These variables were also detected as independent adverse prognostic factors for OS in OM-CMML. These data support the consideration of OM-CMML as the first evolutionary stage within the proliferative continuum of CMML.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Society of Hematology
dc.rights Copyright © 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode, permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
dc.subject.other Leucèmia
dc.subject.other Leucèmia mieloide
dc.title Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1182/bloodadvances.2022007359
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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