Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Calvo González, Xavier
  • dc.contributor.author Roman-Bravo, David
  • dc.contributor.author García Gisbert, Nieves, 1994-
  • dc.contributor.author Rodriguez-Sevilla, Juan José
  • dc.contributor.author García-Avila, Sara
  • dc.contributor.author Florensa Brichs, Lourdes
  • dc.contributor.author Gibert Fernandez, Joan, 1988-
  • dc.contributor.author Fernández Rodríguez, M. Concepción
  • dc.contributor.author Salido Galeote, Marta
  • dc.contributor.author Puiggros Metje, Anna Maria
  • dc.contributor.author Espinet Solà, Blanca
  • dc.contributor.author Colomo Saperas, Luis Alberto
  • dc.contributor.author Bellosillo Paricio, Beatriz
  • dc.contributor.author Ferrer, Ana
  • dc.contributor.author Arenillas Rocha, Leonor
  • dc.date.accessioned 2022-10-07T06:28:17Z
  • dc.date.available 2022-10-07T06:28:17Z
  • dc.date.issued 2022
  • dc.description.abstract atients with oligomonocytic chronic myelomonocytic leukemia (OM-CMML) are currently classified according to the 2017 World Health Organization myelodysplastic syndromes classification. However, recent data support considering OM-CMML as a specific subtype of chronic myelomonocytic leukemia (CMML), given their similar clinical, genomic, and immunophenotypic profiles. The main purpose of our study was to provide survival outcome data of a well-annotated series of 42 patients with OM-CMML and to compare them to 162 patients with CMML, 120 with dysplastic type (D-CMML), and 42 with proliferative type (P-CMML). OM-CMML had significantly longer overall survival (OS) and acute myeloid leukemia-free survival than did patients with CMML, considered as a whole group, and when compared with D-CMML and P-CMML. Moreover, gene mutations associated with increased proliferation (ie, ASXL1 and RAS-pathway mutations) were identified as independent adverse prognostic factors for OS in our series. We found that at a median follow-up of 53.47 months, 29.3% of our patients with OM-CMML progressed to D-CMML, and at a median follow-up of 46.03 months, 28.6% of our D-CMML group progressed to P-CMML. These data support the existence of an evolutionary continuum of OM-CMML, D-CMML, and P-CMML. In this context, we observed that harboring more than 3 mutated genes, carrying ASXL1 mutations, and a peripheral blood monocyte percentage >20% significantly predicted a shorter time of progression of OM-CMML into overt CMML. These variables were also detected as independent adverse prognostic factors for OS in OM-CMML. These data support the consideration of OM-CMML as the first evolutionary stage within the proliferative continuum of CMML.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Calvo X, Roman-Bravo D, Garcia-Gisbert N, Rodriguez-Sevilla JJ, Garcia-Avila S, Florensa L, et al. Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum. Blood Adv. 2022 Jul 12; 6(13): 3921-31. DOI: 10.1182/bloodadvances.2022007359
  • dc.identifier.doi http://dx.doi.org/10.1182/bloodadvances.2022007359
  • dc.identifier.issn 2473-9529
  • dc.identifier.uri http://hdl.handle.net/10230/54311
  • dc.language.iso eng
  • dc.publisher American Society of Hematology
  • dc.rights Copyright © 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode, permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  • dc.subject.other Leucèmia
  • dc.subject.other Leucèmia mieloide
  • dc.title Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)