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Usefulness of cardiac computed tomography in coronary risk prediction: A five-year follow-up of the SPICA study (Secure Prevention with Imaging of the Coronary Arteries)

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dc.contributor.author Viladés-Medel, David
dc.contributor.author Dégano, Irene R.
dc.contributor.author Subirana Cachinero, Isaac
dc.contributor.author Descalzo, Martin
dc.contributor.author Padilla, Mireia
dc.contributor.author Mundet-Tudurí, Xavier
dc.contributor.author Carreras Costa, Francesc
dc.contributor.author Alomar Serrallach, Xavier
dc.contributor.author Camps-Vilaró, Anna
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author Leta Petracca, Rubén
dc.date.accessioned 2022-10-04T06:16:50Z
dc.date.available 2022-10-04T06:16:50Z
dc.date.issued 2022
dc.identifier.citation Viladés-Medel D, Dégano IR, Subirana I, Descalzo M, Padilla M, Mundet X, Carreras Costa F, Alomar Serrallach X, Camps A, Elosua R, Marrugat J, Leta Petracca R. Usefulness of cardiac computed tomography in coronary risk prediction: A five-year follow-up of the SPICA study (Secure Prevention with Imaging of the Coronary Arteries). J Clin Med. 2022 Jan 21;11(3):533. DOI: 10.3390/jcm11030533
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/54244
dc.description.abstract Accurate identification of individuals at high coronary risk would reduce acute coronary syndrome incidence and morbi-mortality. We analyzed the effect on coronary risk prediction of adding coronary artery calcification (CAC) and Segment Involvement Score (SIS) to cardiovascular risk factors. This was a prospective cohort study of asymptomatic patients recruited between 2013-2017. All participants underwent a coronary computed tomography angiography to determine CAC and SIS. The cohort was followed-up for a composite endpoint of myocardial infarction, coronary angiography and/or revascularization (median = five years). Discrimination and reclassification of the REGICOR function with CAC/SIS were examined with the Sommer's D index and with the Net reclassification index (NRI). Nine of the 251 individuals included had an event. Of the included participants, 94 had a CAC = 0 and 85 a SIS = 0, none of them had an event. The addition of SIS or of SIS and CAC to the REGICOR risk function significantly increased the discrimination capacity from 0.74 to 0.89. Reclassification improved significantly when SIS or both scores were included. CAC and SIS were associated with five-year coronary event incidence, independently of cardiovascular risk factors. Discrimination and reclassification of the REGICOR risk function were significantly improved by both indexes, but SIS overrode the effect of CAC.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof J Clin Med. 2022 Jan 21;11(3):533
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Usefulness of cardiac computed tomography in coronary risk prediction: A five-year follow-up of the SPICA study (Secure Prevention with Imaging of the Coronary Arteries)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm11030533
dc.subject.keyword Cardiac computed tomography
dc.subject.keyword Coronary artery calcium
dc.subject.keyword Coronary artery disease risk
dc.subject.keyword Primary prevention
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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