Usefulness of cardiac computed tomography in coronary risk prediction: A five-year follow-up of the SPICA study (Secure Prevention with Imaging of the Coronary Arteries)
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- dc.contributor.author Viladés-Medel, David
- dc.contributor.author Dégano, Irene R.
- dc.contributor.author Subirana Cachinero, Isaac
- dc.contributor.author Descalzo, Martin
- dc.contributor.author Padilla, Mireia
- dc.contributor.author Mundet-Tudurí, Xavier
- dc.contributor.author Carreras Costa, Francesc
- dc.contributor.author Alomar Serrallach, Xavier
- dc.contributor.author Camps-Vilaró, Anna
- dc.contributor.author Elosua Llanos, Roberto
- dc.contributor.author Marrugat de la Iglesia, Jaume
- dc.contributor.author Leta Petracca, Rubén
- dc.date.accessioned 2022-10-04T06:16:50Z
- dc.date.available 2022-10-04T06:16:50Z
- dc.date.issued 2022
- dc.description.abstract Accurate identification of individuals at high coronary risk would reduce acute coronary syndrome incidence and morbi-mortality. We analyzed the effect on coronary risk prediction of adding coronary artery calcification (CAC) and Segment Involvement Score (SIS) to cardiovascular risk factors. This was a prospective cohort study of asymptomatic patients recruited between 2013-2017. All participants underwent a coronary computed tomography angiography to determine CAC and SIS. The cohort was followed-up for a composite endpoint of myocardial infarction, coronary angiography and/or revascularization (median = five years). Discrimination and reclassification of the REGICOR function with CAC/SIS were examined with the Sommer's D index and with the Net reclassification index (NRI). Nine of the 251 individuals included had an event. Of the included participants, 94 had a CAC = 0 and 85 a SIS = 0, none of them had an event. The addition of SIS or of SIS and CAC to the REGICOR risk function significantly increased the discrimination capacity from 0.74 to 0.89. Reclassification improved significantly when SIS or both scores were included. CAC and SIS were associated with five-year coronary event incidence, independently of cardiovascular risk factors. Discrimination and reclassification of the REGICOR risk function were significantly improved by both indexes, but SIS overrode the effect of CAC.
- dc.format.mimetype application/pdf
- dc.identifier.citation Viladés-Medel D, Dégano IR, Subirana I, Descalzo M, Padilla M, Mundet X, Carreras Costa F, Alomar Serrallach X, Camps A, Elosua R, Marrugat J, Leta Petracca R. Usefulness of cardiac computed tomography in coronary risk prediction: A five-year follow-up of the SPICA study (Secure Prevention with Imaging of the Coronary Arteries). J Clin Med. 2022 Jan 21;11(3):533. DOI: 10.3390/jcm11030533
- dc.identifier.doi http://dx.doi.org/10.3390/jcm11030533
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/54244
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof J Clin Med. 2022 Jan 21;11(3):533
- dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cardiac computed tomography
- dc.subject.keyword Coronary artery calcium
- dc.subject.keyword Coronary artery disease risk
- dc.subject.keyword Primary prevention
- dc.title Usefulness of cardiac computed tomography in coronary risk prediction: A five-year follow-up of the SPICA study (Secure Prevention with Imaging of the Coronary Arteries)
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion