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The GenoDiabMar registry: A collaborative research platform of type 2 diabetes patients

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dc.contributor.author Sierra, Adriana
dc.contributor.author Otero, Sol
dc.contributor.author Rodríguez, Eva
dc.contributor.author Faura, Anna
dc.contributor.author Vera, María
dc.contributor.author Riera, Marta
dc.contributor.author Palau González, Vanesa
dc.contributor.author Duran Jordà, Xavier, 1974-
dc.contributor.author Costa-Garrido, Anna
dc.contributor.author Sans Atxer, Laia
dc.contributor.author Márquez, Eva
dc.contributor.author Poposki, Vladimir
dc.contributor.author Franch-Nadal, Josep
dc.contributor.author Mundet-Tudurí, Xavier
dc.contributor.author Oliveras, Anna
dc.contributor.author Crespo Barrio, Marta
dc.contributor.author Pascual Santos, Julio
dc.contributor.author Barrios Barrera, Clara
dc.date.accessioned 2022-10-04T06:16:46Z
dc.date.available 2022-10-04T06:16:46Z
dc.date.issued 2022
dc.identifier.citation Sierra A, Otero S, Rodríguez E, Faura A, Vera M, Riera M, Palau V, Durán X, Costa-Garrido A, Sans L, Márquez E, Poposki V, Franch-Nadal J, Mundet X, Oliveras A, Crespo M, Pascual J, Barrios C. The GenoDiabMar registry: A collaborative research platform of type 2 diabetes patients. J Clin Med. 2022 Mar 5;11(5):1431. DOI: 10.3390/jcm11051431
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/54243
dc.description.abstract The GenoDiabMar registry is a prospective study that aims to provide data on demographic, biochemical, and clinical changes in type 2 diabetic (T2D) patients attending real medical outpatient consultations. This registry is also used to find new biomarkers related to the micro- and macrovascular complications of T2D, with a particular focus on diabetic nephropathy. With this purpose, longitudinal serum and urine samples, DNA banking, and data on 227 metabolomics profiles, 77 immunoglobulin G glycomics traits, and other emerging biomarkers were recorded in this cohort. In this study, we show a detailed longitudinal description of the clinical and analytical parameters of this registry, with a special focus on the progress of renal function and cardiovascular events. The main objective is to analyze whether there are differential risk factors for renal function deterioration between sexes, as well as to analyze cardiovascular events and mortality in this population. In total, 650 patients with a median age of 69 (14) with different grades of chronic kidney disease-G1-G2 (eGFR > 90-60 mL/min/1.73 m2) 50.3%, G3 (eGFR; 59-30 mL/min/1.73 m2) 31.4%, G4 (eGFR; 29-15 mL/min/1.73 m2) 10.8%, and G5 (eGFR < 15 mL/min/1.73 m2) 7.5%-were followed up for 4.7 (0.65) years. Regardless of albuminuria, women lost 0.93 (0.40-1.46) fewer glomerular filtration units per year than men. A total of 17% of the participants experienced rapid deterioration of renal function, 75.2% of whom were men, with differential risk factors between sexes-severe macroalbuminuria > 300 mg/g for men OR [IQ] 2.40 [1.29:4.44] and concomitant peripheral vascular disease 3.32 [1.10:9.57] for women. Overall mortality of 23% was detected (38% of which was due to cardiovascular etiology). We showed that kidney function declined faster in men, with different risk factors compared to women. Patients with T2D and kidney involvement have very high mortality and an important cardiovascular burden. This cohort is proposed as a great tool for scientific collaboration for studies, whether they are focused on T2D, or whether they are interested in comparing differential markers between diabetic and non-diabetic populations.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof J Clin Med. 2022 Mar 5;11(5):1431
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title The GenoDiabMar registry: A collaborative research platform of type 2 diabetes patients
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm11051431
dc.subject.keyword Diabetes complication
dc.subject.keyword Epidemiology
dc.subject.keyword Multiomic collaborative platform
dc.subject.keyword Real-world patient registry
dc.subject.keyword Renal function
dc.subject.keyword Sex differences
dc.subject.keyword Type 2 diabetes
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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