The GenoDiabMar registry: A collaborative research platform of type 2 diabetes patients

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• dc.contributor.author Sierra, Adriana
• dc.contributor.author Otero, Sol
• dc.contributor.author Rodríguez, Eva
• dc.contributor.author Faura, Anna
• dc.contributor.author Vera, María
• dc.contributor.author Riera, Marta
• dc.contributor.author Palau González, Vanesa
• dc.contributor.author Duran Jordà, Xavier, 1974-
• dc.contributor.author Costa-Garrido, Anna
• dc.contributor.author Sans Atxer, Laia
• dc.contributor.author Márquez, Eva
• dc.contributor.author Poposki, Vladimir
• dc.contributor.author Franch-Nadal, Josep
• dc.contributor.author Mundet-Tudurí, Xavier
• dc.contributor.author Oliveras, Anna
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author Barrios Barrera, Clara
• dc.date.accessioned 2022-10-04T06:16:46Z
• dc.date.available 2022-10-04T06:16:46Z
• dc.date.issued 2022
• dc.description.abstract The GenoDiabMar registry is a prospective study that aims to provide data on demographic, biochemical, and clinical changes in type 2 diabetic (T2D) patients attending real medical outpatient consultations. This registry is also used to find new biomarkers related to the micro- and macrovascular complications of T2D, with a particular focus on diabetic nephropathy. With this purpose, longitudinal serum and urine samples, DNA banking, and data on 227 metabolomics profiles, 77 immunoglobulin G glycomics traits, and other emerging biomarkers were recorded in this cohort. In this study, we show a detailed longitudinal description of the clinical and analytical parameters of this registry, with a special focus on the progress of renal function and cardiovascular events. The main objective is to analyze whether there are differential risk factors for renal function deterioration between sexes, as well as to analyze cardiovascular events and mortality in this population. In total, 650 patients with a median age of 69 (14) with different grades of chronic kidney disease-G1-G2 (eGFR > 90-60 mL/min/1.73 m2) 50.3%, G3 (eGFR; 59-30 mL/min/1.73 m2) 31.4%, G4 (eGFR; 29-15 mL/min/1.73 m2) 10.8%, and G5 (eGFR < 15 mL/min/1.73 m2) 7.5%-were followed up for 4.7 (0.65) years. Regardless of albuminuria, women lost 0.93 (0.40-1.46) fewer glomerular filtration units per year than men. A total of 17% of the participants experienced rapid deterioration of renal function, 75.2% of whom were men, with differential risk factors between sexes-severe macroalbuminuria > 300 mg/g for men OR [IQ] 2.40 [1.29:4.44] and concomitant peripheral vascular disease 3.32 [1.10:9.57] for women. Overall mortality of 23% was detected (38% of which was due to cardiovascular etiology). We showed that kidney function declined faster in men, with different risk factors compared to women. Patients with T2D and kidney involvement have very high mortality and an important cardiovascular burden. This cohort is proposed as a great tool for scientific collaboration for studies, whether they are focused on T2D, or whether they are interested in comparing differential markers between diabetic and non-diabetic populations.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sierra A, Otero S, Rodríguez E, Faura A, Vera M, Riera M, Palau V, Durán X, Costa-Garrido A, Sans L, Márquez E, Poposki V, Franch-Nadal J, Mundet X, Oliveras A, Crespo M, Pascual J, Barrios C. The GenoDiabMar registry: A collaborative research platform of type 2 diabetes patients. J Clin Med. 2022 Mar 5;11(5):1431. DOI: 10.3390/jcm11051431
• dc.identifier.doi http://dx.doi.org/10.3390/jcm11051431
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/54243
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Clin Med. 2022 Mar 5;11(5):1431
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Diabetes complication
• dc.subject.keyword Epidemiology
• dc.subject.keyword Multiomic collaborative platform
• dc.subject.keyword Real-world patient registry
• dc.subject.keyword Renal function
• dc.subject.keyword Sex differences
• dc.subject.keyword Type 2 diabetes
• dc.title The GenoDiabMar registry: A collaborative research platform of type 2 diabetes patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion