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Aging impairs reverse remodeling and recovery of ventricular function after isoproterenol-induced cardiomyopathy

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dc.contributor.author Yáñez Bisbe, Laia, 1993-
dc.contributor.author Garcia-Elias Heras, Anna
dc.contributor.author Tajes Orduña, Marta
dc.contributor.author Almendros, Isaac
dc.contributor.author Rodríguez-Sinovas, Antonio
dc.contributor.author Inserte, Javier
dc.contributor.author Ruiz-Meana, Marisol
dc.contributor.author Farré, Ramon
dc.contributor.author Farré López, Núria
dc.contributor.author Benito Villabriga, Begoña
dc.date.accessioned 2022-09-23T06:23:32Z
dc.date.available 2022-09-23T06:23:32Z
dc.date.issued 2022
dc.identifier.citation Yáñez-Bisbe L, Garcia-Elias A, Tajes M, Almendros I, Rodríguez-Sinovas A, Inserte J, Ruiz-Meana M, Farré R, Farré N, Benito B. Aging impairs reverse remodeling and recovery of ventricular function after isoproterenol-induced cardiomyopathy. Int J Mol Sci. 2021 Dec 24;23(1):174. DOI: 10.3390/ijms23010174
dc.identifier.issn 1422-0067
dc.identifier.uri http://hdl.handle.net/10230/54169
dc.description.abstract Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We investigated the vulnerability to develop HFrEF in female elderly mice compared to young animals, as well as potential differences in reverse remodeling. First, HF was induced by isoproterenol infusion (30 mg/kg/day, 28 days) in young (10-week-old) and elderly (22-month-old) female mice. In a second set of animals, mice underwent isoproterenol infusion followed by no treatment during 28 additional days. Cardiac remodeling was assessed by echocardiography, histology and gene expression of collagen-I and collagen-III. Following isoproterenol infusion, elderly mice developed similar HFrEF features compared to young animals, except for greater cell hypertrophy and tissue fibrosis. After beta-adrenergic withdrawal, young female mice experienced complete reversal of the HFrEF phenotype. Conversely, reversed remodeling was impaired in elderly animals, with no significant recovery of LV ejection fraction, cardiomyocyte hypertrophy and collagen deposition. In conclusion, chronic isoproterenol infusion is a valid HF model for elderly and young female mice and induces a similar HF phenotype in both. Elderly animals, unlike young, show impaired reverse remodeling, with persistent tissue fibrosis and cardiac dysfunction even after beta-adrenergic withdrawal.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Int J Mol Sci. 2021 Dec 24;23(1):174
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Aging impairs reverse remodeling and recovery of ventricular function after isoproterenol-induced cardiomyopathy
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijms23010174
dc.subject.keyword HFrEF
dc.subject.keyword Ageing
dc.subject.keyword Cardiac remodeling
dc.subject.keyword Female animals
dc.subject.keyword Heart failure
dc.subject.keyword Reverse remodeling
dc.subject.keyword Ventricular dysfunction
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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